Results 61 to 70 of about 2,177,035 (249)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Can Ultrasound Pixel Density Serve as a Non-Invasive Alternative to Thoracentesis in Classifying Pleural Effusions?

Journal of Sharif Medical & Dental College
Objective: To determine the diagnostic performance of ultrasound pixel density in differentiating exudative from transudative pleural effusions, using Light’s criteria as the gold standard.
Aqsa Javaid, Muhammad Zill-e-Humayun Mirza, Muhammad Khalid Azam Khan, Asif Ullah Khan, Naveed Anjum, Muhammad Hamza   +5 more
doaj   +1 more source

Role of pleural fluid-serum protein carbonyl gradient in differentiating exudative and transudative effusions

Asian Journal of Medical Sciences, 2020
Background: Pleural effusions often cause a diagnostic dilemma. The first step in the evaluation of pleural effusions is the distinction between exudates and transudates.
Raghumoy Ghosh , Kheya Mukherjee , Saumyajit Maiti , Debojyoti Bhattacharjee , Shubho Chowdhuri   +4 more
doaj   +1 more source

To Study the Combined use of Pleural Fluid Lymphocyte / Neutrophil Ratio and Ada for the Diagnosis of Tuberculous Pleural Effusion [PDF]

, 2017
AIMS AND OBJECTIVES: To determine whether the combined use of ADA activity and lymphocyte/neutrophil ratio would provide a more efficient means for diagnosing tuberculouspleural effusion than with the use of ADA alone. MATERIALS AND METHODS: Design of
Suresh, R
core  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Discriminative performance of serum, pleural fluid, and gradient high-sensitivity C-reactive protein in pleural effusions

The Egyptian Journal of Bronchology
Background Pleural effusion is a common clinical condition with diverse etiologies. Differentiating exudative from transudative pleural effusions is essential for appropriate diagnosis and management. High-sensitivity C-reactive protein (hs-CRP) has been
Putri Annisa Melia Sari, Nindia Sugih Arto, Ricke Loesnihari, Andika Pradana, Sylvia Youvella   +4 more
doaj   +1 more source

Usefulness of pleural fluid uric acid and its ratio to serum uric acid levels in classifying pleural effusions as exudates and transudates and its correlation with light’s criteria [PDF]

, 2018
INTRODUCTION: Pleural effusion is a very common clinical presentation of diseases. A correct diagnosis of the underlying disease is essential for the management of pleural effusion.
Karuppasamy, P
core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Transudative pleural effusion of malignant etiology: Rare but real

Respiratory Medicine Case Reports, 2017
A 62-year-old female presented to the emergency room with one-month history of epigastric abdominal pain, nausea and vomiting. She endorsed progressive dyspnea over two weeks.
Lindsey Johnson, MD, Hafiz Abdul Moiz Fakih, MD, Salim Daouk, MD, Shaheera Saleem, Ali Ataya, MD   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source