Results 91 to 100 of about 7,864,360 (280)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Simulation-based insights into light soaking and light-induced degradation in perovskite solar cells

EPJ Photovoltaics
Perovskite solar cells have achieved remarkable power conversion efficiencies, yet their long-term stability remains a critical challenge. Progress in understanding this issue can be supported by combining modelling and characterization of the ...
Álvarez Pérez Guillem, Medjoubi Karim, Julien Arthur, Puel Jean-Baptiste, Guillemoles Jean-François   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Surface Decorated Zn0.15Cd0.85S Nanoflowers with P25 for Enhanced Visible Light Driven Photocatalytic Degradation of Rh-B and Stability

Applied Sciences, 2018
Decoration of Zn0.15Cd0.85S nanoflowers with P25 for forming P25/Zn0.15Cd0.85S nanocomposite has been successfully synthesized with fine crystallinity by one-step low temperature hydrothermal method.
Muneerah Alomar, Yueli Liu, Wen Chen
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PPKs mediate direct signal transfer from phytochrome photoreceptors to transcription factor PIF3

Nature Communications, 2017
Phytochrome photoreceptors mediate degradation of PIF transcription factors in the nucleus in response to light. Here Niet al. identify a family of nuclear protein kinases that interact with photoactivated phytochrome B and facilitate phytochrome-induced
Weimin Ni, Shou-Ling Xu, Eduardo González-Grandío, Robert J. Chalkley, Andreas F. R. Huhmer, Alma L. Burlingame, Zhi-Yong Wang, Peter H. Quail   +7 more
doaj   +1 more source

Impact of Hydrogen Concentration on the Regeneration of Light Induced Degradation

Energy Procedia, 2011
AbstractThe permanent deactivation called regeneration of light induced degradation in p-type Czochralski silicon solar cells is analyzed in this paper. Industrial solar cells were fabricated with varying hydrogen concentration in the silicon nitride anti-reflection layer but with an otherwise identical setup.
Krugel, Georg, Wolke, Winfried, Geilker, Juliane, Rein, Stefan, Preu, Ralf   +4 more
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Visible-light induced degradation of diphenyl urea and polyethylene using polythiophene decorated CuFe₂O₄ nanohybrids. [PDF]

Sci Rep, 2023
Riaz U, Gaffar S, Hauser K, Yan F.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source