Results 101 to 110 of about 7,864,360 (280)

Insights into Photo Degradation and Stabilization Strategies of Antibody–Drug Conjugates with Camptothecin Payloads

Pharmaceutics
Background: Photostability assessment is a critical component in the development of drug products, particularly for antibody–drug conjugates (ADCs) containing light-sensitive small molecules such as camptothecin (CPT) and its derivatives. ADCs conjugated
Shukun Luo, Joshua Bulos, Ricky Uroza, Yimeng Zhao, Xiao Pan, Yue Su, Haibo Qiu, Babatunde Olagunju, Wenhua Wang, Dingjiang Liu, Mohammed Shameem   +10 more
doaj   +1 more source

High-Light-Induced Degradation of Photosystem II Subunits' Involvement in the Albino Phenotype in Tea Plants. [PDF]

Int J Mol Sci, 2022
Cai WH, Zheng XQ, Liang YR.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Fabrication of FeVO₄/RGO Nanocomposite: An Amperometric Probe for Sensitive Detection of Methyl Parathion in Green Beans and Solar Light-Induced Degradation. [PDF]

ACS Omega, 2022
Alsulami A, Kumarswamy YK, Prashanth MK, Hamzada S, Lakshminarayana P, Pradeep Kumar CB, Jeon BH, Raghu MS.   +7 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Multistage performance deterioration in n-type crystalline silicon photovoltaic modules undergoing potential-induced degradation [PDF]

, 2018
This study addresses the behavior of n-type front-emitter (FE) crystalline-silicon (c-Si) photovoltaic (PV) modules in potential-induced degradation (PID) tests with a long duration of up to 20 days.
Masuda, Atsushi, Yamaguchi, Seira, Komatsu, Yutaka, Atsushi Masuda, Yutaka Komatsu, Keisuke Ohdaira, Ohdaira, Keisuke, Seira Yamaguchi   +7 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Investigations on Amphoteric Chitosan/TiO2 Bionanocomposites for Application in Visible Light Induced Photocatalytic Degradation

Advances in Polymer Technology, 2019
The present investigation reports the greener synthesis and characterization of novel acrylic acid grafted amphoteric chitosan/TiO2 (CAT) bionanocomposites using ultrasonic radiations.
M. Bahal, N. Kaur, Nidhi Sharotri, Dhiraj Sud   +3 more
doaj   +1 more source

Liquid Core Waveguide Cell with In Situ Absorbance Spectroscopy and Coupled to Liquid Chromatography for Studying Light-Induced Degradation. [PDF]

Anal Chem, 2022
Groeneveld I, Bagdonaite I, Beekwilder E, Ariese F, Somsen GW, van Bommel MR.   +5 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source