Results 101 to 110 of about 2,711,435 (306)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Ultrasound-assisted immersion freezing improves the digestion properties of beef myofibrillar protein

Food Chemistry: X
This study focused on the effect of ultrasound-assisted immersion freezing (UIF) with different ultrasound power (200, 400, 600 W) on the physicochemical and in vitro digestive properties of beef myofibrillar proteins (BMP).
Junguang Li, Chenhao Sun, Xiaonan Yue, Wuchao Ma, Yu Wang, Jiansheng Zhao, Guangsu Zhu, Yanhong Bai   +7 more
doaj   +1 more source

Physiological Characteristics and Transcriptomic Analysis of Saccharomyces cerevisiae under Carvacrol Stress [PDF]

Shipin Kexue
This study investigated the effect of carvacrol stress on the physiological characteristics and transcriptome of Saccharomyces cerevisiae, a common spoilage yeast in fruit and vegetable products.
NIU Liyuan, SUN Xiaocheng, LIU Jingfei, WU Zihao, BAI Yanhong, ZHANG Zhijian
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Anthocyanin-loaded complexes of glycated dual milk-derived proteins: thermal stability, storage stability, and simulated digestion

Ultrasonics Sonochemistry
Anthocyanin (ACN) have attracted considerable scholarly attention owing to exceptional biological activities. Nonetheless, their limited stability and bioavailability present significant challenges to practical applications.
Shuangshuang Wang, Zhenzhu Li, Qingshuang Qiu, Huilin Lv, Haokun Zhang, Hang Wang, Rongzu Nie, Wupeng Ge, Peifeng Li   +8 more
doaj   +1 more source

Static and Dynamic Chain Structures in the Mean-Field Theory

, 2011
We give a brief overview of recent work examining the presence of $\alpha$-clusters in light nuclei within the Skyrme-force Hartree-Fock model. Of special significance are investigations into $\alpha$-chain structures in carbon isotopes and $^{16}$O ...
Ichikawa, T., Itagaki, N., Loebl, N., Maruhn, J. A., Oberacker, V. E., Ohkubo, S., Schuetrumpf, B., Umar, A. S.   +7 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Application of Cyclodextrins Stabilized Pickering Emulsion in Gluten-free Rice Bread

Shipin gongye ke-ji
To investigate the effect of cyclodextrins (CDs) stabilized Pickering emulsions on the quality of gluten-free rice bread, the corn oil Pickering emulsions stabilized by α-CD, β-CD or γ-CD were prepared and applied to gluten-free rice bread respectively ...
Xuehong LI, Jingjing GONG, Minjie LI, Dijia XIN, Lu ZHANG, Yong LU   +5 more
doaj   +1 more source

Colorimetric Method Based on CeO2/CoOOH Nanozyme for Rapid Detection of Ascorbic Acid in Fruits [PDF]

Shipin Kexue
In this study, cerium dioxide-modified cobalt oxyhydroxide (CeO2/CoOOH) nanomaterial was synthesized by a liquid-phase precipitation method. CeO2/CoOOH showed good oxidase-like activity toward 3,3’,5,5’-tetramethylbenzidine (TMB), and could directly ...
YUE Xiaoyue, WU Chaoyun, YAN Shuliang, FU Long, ZHAO Dianbo
doaj   +1 more source

More light shed on light chains [PDF]

Nephrology Dialysis Transplantation, 2014
Paisit, Paueksakon, Agnes B, Fogo
openaire   +2 more sources