Results 261 to 270 of about 2,711,435 (306)
Some of the next articles are maybe not open access.
2018
Calcium ions (Ca2+) has been recognized as an important component in muscle contraction and cell motility because it regulates a distinct class of protein kinases, myosin light chain kinases. Striated muscles, including cardiac and skeletal muscle tissues, have served as useful models for studying the mechanism by which Ca2+ regulates contractile ...
Kemp, Bruce E., Stull, James T.
openaire +3 more sources
Calcium ions (Ca2+) has been recognized as an important component in muscle contraction and cell motility because it regulates a distinct class of protein kinases, myosin light chain kinases. Striated muscles, including cardiac and skeletal muscle tissues, have served as useful models for studying the mechanism by which Ca2+ regulates contractile ...
Kemp, Bruce E., Stull, James T.
openaire +3 more sources
Shedding a little light on light chains
Nature Cell Biology, 2001Myosin II regulatory light chains have an important role in the organization and function of the contractile machinery at cytokinesis. Two recent reports provide new insights into these important proteins.
D P, Mulvihill, J S, Hyams
openaire +2 more sources
Free light chains and heavy/light chains in monitoring POEMS patients
Clinical Chemistry and Laboratory Medicine (CCLM), 2016AbstractPOEMS syndrome is defined by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes. The vascular endothelial growth factor (VEGF) appears to play a key role in the pathogenesis of the syndrome, and its concentrations are deemed to correlate to disease activity.
Altinier, S +9 more
openaire +3 more sources
Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis
2007Light-chain amyloidosis (AL) is characterized by the clonal expansion of plasma B cells that secrete large amounts of monoclonal immunoglobulin light chains. The free light chains circulate in serum and form amyloid fibrils on vital organs such as the kidney, heart, and liver causing organ failure and eventually death.
Marina Ramirez-Alvarado +5 more
openaire +1 more source
Nature, 1969
MYOSIN from rabbit skeletal muscle contains low molecular weight proteins (light chains) as well as the two large polypeptide chains which comprise the bulk of the molecule. Alkali treatment has been used1–4 to separate the light from the heavy chains, and they have been characterized by gel electrophoresis and in the ultracentrifuge.
openaire +2 more sources
MYOSIN from rabbit skeletal muscle contains low molecular weight proteins (light chains) as well as the two large polypeptide chains which comprise the bulk of the molecule. Alkali treatment has been used1–4 to separate the light from the heavy chains, and they have been characterized by gel electrophoresis and in the ultracentrifuge.
openaire +2 more sources
Light Chain-Mediated Tubulopathies
2011Immunoglobulin light chains are low molecular weight proteins that are filtered through the glomerulus and reabsorbed into the proximal tubular epithelium by binding initially to a heteromeric receptor complex composed of megalin and cubilin. Saturation of this receptor-mediated endocytotic process results in the presence of free light chains in the ...
openaire +2 more sources
2016
Light-chain (AL) amyloidosis is the most common cause of acquired systemic amyloidosis. It is a highly heterogeneous disease with a wide spectrum of clinical presentation. Prognosis of AL amyloidosis depends on organ, particularly cardiac, involvement.
Amara S. Hussain, Anita D’Souza
openaire +1 more source
Light-chain (AL) amyloidosis is the most common cause of acquired systemic amyloidosis. It is a highly heterogeneous disease with a wide spectrum of clinical presentation. Prognosis of AL amyloidosis depends on organ, particularly cardiac, involvement.
Amara S. Hussain, Anita D’Souza
openaire +1 more source
Innere Medizin (Heidelberg, Germany), 2023
Light chain amyloidosis (AL) is a rare protein deposition disease. It is caused by a clonal plasma cell or B‑cell disease in the bone marrow. With the exception of the central nervous system, all organs can be affected by amyloid deposits. Cardiac involvement is the most frequent organ manifestation that leads to significantly increased mortality when ...
Ute, Hegenbart +2 more
openaire +1 more source
Light chain amyloidosis (AL) is a rare protein deposition disease. It is caused by a clonal plasma cell or B‑cell disease in the bone marrow. With the exception of the central nervous system, all organs can be affected by amyloid deposits. Cardiac involvement is the most frequent organ manifestation that leads to significantly increased mortality when ...
Ute, Hegenbart +2 more
openaire +1 more source
Light chain crystalline podocytopathy
Kidney International, 2021Samih H, Nasr +2 more
openaire +2 more sources