Results 271 to 280 of about 1,009,600 (313)
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Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis
2007Light-chain amyloidosis (AL) is characterized by the clonal expansion of plasma B cells that secrete large amounts of monoclonal immunoglobulin light chains. The free light chains circulate in serum and form amyloid fibrils on vital organs such as the kidney, heart, and liver causing organ failure and eventually death.
Marina Ramirez-Alvarado +5 more
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Nature, 1969
MYOSIN from rabbit skeletal muscle contains low molecular weight proteins (light chains) as well as the two large polypeptide chains which comprise the bulk of the molecule. Alkali treatment has been used1–4 to separate the light from the heavy chains, and they have been characterized by gel electrophoresis and in the ultracentrifuge.
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MYOSIN from rabbit skeletal muscle contains low molecular weight proteins (light chains) as well as the two large polypeptide chains which comprise the bulk of the molecule. Alkali treatment has been used1–4 to separate the light from the heavy chains, and they have been characterized by gel electrophoresis and in the ultracentrifuge.
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Light Chain-Mediated Tubulopathies
2011Immunoglobulin light chains are low molecular weight proteins that are filtered through the glomerulus and reabsorbed into the proximal tubular epithelium by binding initially to a heteromeric receptor complex composed of megalin and cubilin. Saturation of this receptor-mediated endocytotic process results in the presence of free light chains in the ...
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2016
Light-chain (AL) amyloidosis is the most common cause of acquired systemic amyloidosis. It is a highly heterogeneous disease with a wide spectrum of clinical presentation. Prognosis of AL amyloidosis depends on organ, particularly cardiac, involvement.
Amara S. Hussain, Anita D’Souza
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Light-chain (AL) amyloidosis is the most common cause of acquired systemic amyloidosis. It is a highly heterogeneous disease with a wide spectrum of clinical presentation. Prognosis of AL amyloidosis depends on organ, particularly cardiac, involvement.
Amara S. Hussain, Anita D’Souza
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Innere Medizin (Heidelberg, Germany), 2023
Light chain amyloidosis (AL) is a rare protein deposition disease. It is caused by a clonal plasma cell or B‑cell disease in the bone marrow. With the exception of the central nervous system, all organs can be affected by amyloid deposits. Cardiac involvement is the most frequent organ manifestation that leads to significantly increased mortality when ...
Ute, Hegenbart +2 more
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Light chain amyloidosis (AL) is a rare protein deposition disease. It is caused by a clonal plasma cell or B‑cell disease in the bone marrow. With the exception of the central nervous system, all organs can be affected by amyloid deposits. Cardiac involvement is the most frequent organ manifestation that leads to significantly increased mortality when ...
Ute, Hegenbart +2 more
openaire +1 more source
Light chain crystalline podocytopathy
Kidney International, 2021Samih H, Nasr +2 more
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Planning for post‐pandemic cancer care delivery: Recovery or opportunity for redesign?
Ca-A Cancer Journal for Clinicians, 2021Pelin Cinar +2 more
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Systemic Light Chain Amyloidosis
New England Journal of MedicineMaurizio, Marvisi, Sara, Ramponi
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A roadmap for the commercialization of perovskite light emitters
Nature Reviews Materials, 2022, Richard Friend, Edward H Sargent
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