Results 21 to 30 of about 1,009,600 (313)

Kappa light chain nephropathy

Cleveland Clinic Journal of Medicine, 1983
Kappa light chain nephropathy is described in a 45- year-old man who presented with weight loss, anorexia, and unexplained renal failure.
W. R. Hart, G. N. Gephardt
openaire   +2 more sources

Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1

mAbs
In contrast to natural antibodies that rely mainly on the heavy chain to establish contacts with their cognate antigen, we have developed a bispecific antibody format in which the light chain (LC) drives antigen binding and specificity.
Pauline Malinge, Xavier Chauchet, Jérémie Bourguignon, Nicolas Bosson, Sébastien Calloud, Tereza Bautzova, Marie Borlet, Mette Laursen, Vinardas Kelpsas, Nadia Rose, Franck Gueneau, Ulla Ravn, Giovanni Magistrelli, Nicolas Fischer   +13 more
doaj   +1 more source

Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody

Frontiers in Immunology
BackgroundBlocking the CD47 “don’t eat me”-signal on tumor cells with monoclonal antibodies or fusion proteins has shown limited clinical activity in hematologic malignancies and solid tumors thus far.
Anja Seckinger, Anja Seckinger, Vanessa Buatois, Valéry Moine, Bruno Daubeuf, Françoise Richard, Laurence Chatel, Alizée Viandier, Nicolas Bosson, Emeline Rousset, Krzysztof Masternak, Susana Salgado-Pires, Claudia Batista, Christelle Mougin, Flora Juan-Bégeot, Yves Poitevin, Dirk Hose, Dirk Hose   +17 more
doaj   +1 more source

Bacillus vallismortis TU-Orga21 blocks rice blast through both direct effect and stimulation of plant defense

Frontiers in Plant Science, 2023
Beneficial microorganisms are an important strategy for sustainable plant production processes such as stimulate root exudation, stress tolerance, and yield improvement.
Wannaporn Thepbandit, Anake Srisuwan, Supatcharee Siriwong, Siriwan Nawong, Dusit Athinuwat, Dusit Athinuwat   +5 more
doaj   +1 more source

Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies

Journal for ImmunoTherapy of Cancer
Background Owing to their roles in promoting T cell and natural killer (NK) cell activation and proliferation, interleukins-2 (IL-2) and interleukins-15 (IL-15) have been pursued as promising pathways to target in cancer immunotherapy. Nonetheless, their
Camilla Jandus, Walter Ferlin, Sébastien Calloud, Alizée Viandier, Pauline Malinge, Nicolas Fischer, Limin Shang, Krzysztof Masternak, Julien Montorfani, Eric Hatterer, Laurence Chatel, Adeline Lesnier, Bruno Daubeuf, Lise Nouveau   +13 more
doaj   +1 more source

Light-chain nephropathy

Kidney International, 1985
Case presentation A 65-year-old woman, first evaluated at New England Medical Center approximately 4 years ago for hypertension, was found to have glycosuria with a concomitant serum glucose level of 95 mg/dl. Serum uric acid was 2.1 mg/dl, the serum phosphorus was 1.8 mg/dl, and the patient had a hyperchioremic metabolic acidosis; the serum ...
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Notch signaling pathway modulation by food functional ingredients: mechanisms, cancer and immunoregulation

Frontiers in Cell and Developmental Biology
This article comprehensively reviews the complex role of the Notch signaling cascade in cancer, as well as the regulatory mechanisms and potential anti-cancer effects of food functional ingredients on this pathway.
Rong-Zu Nie, Rong-Zu Nie, Rong-Zu Nie, Huo-Min Luo, Huo-Min Luo, Huo-Min Luo, Ya-Ping Liu, Ya-Ping Liu, Ya-Ping Liu, Shuang-Shuang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Yan-Jie Hou, Yan-Jie Hou, Yan-Jie Hou, Chen Chen, Chen Chen, Chen Chen, Hang Wang, Hang Wang, Hang Wang, Hui-Lin Lv, Hui-Lin Lv, Hui-Lin Lv, Xing-Yue Tao, Xing-Yue Tao, Xing-Yue Tao, Zhao-Hui Jing, Zhao-Hui Jing, Zhao-Hui Jing, Hao-Kun Zhang, Hao-Kun Zhang, Hao-Kun Zhang, Pei-Feng Li, Pei-Feng Li, Pei-Feng Li   +35 more
doaj   +1 more source

Comparative study of thermal gelation properties and molecular forces of actomyosin extracted from normal and pale, soft and exudative-like chicken breast meat [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective The objectives of this study were to investigate the thermal gelation properties and molecular forces of actomyosin extracted from two classes of chicken breast meat qualities (normal and pale, soft and exudative [PSE]-like) during heating ...
Ke Li, Jun-Ya Liu, Lei Fu, Ying-Ying Zhao, Yan-Hong Bai   +4 more
doaj   +1 more source

Effect of inulin on the pasting and retrogradation characteristics of three different crystalline starches and their interaction mechanism

Frontiers in Nutrition, 2022
At present, there are hardly any studies about the effect of inulin (IN) on the physicochemical properties and structures of different crystalline starches.
Xiaolong Ji, Zhiwen Wang, Xueyuan Jin, Zhenpeng Qian, Le Qin, Xudan Guo, Mingsong Yin, Yanqi Liu   +7 more
doaj   +1 more source