Results 111 to 120 of about 33,909 (239)

Utilization and Prognosis of Cardiac Device Implantation in AL Versus ATTR Amyloidosis

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Cardiac amyloidosis can cause congestive heart failure, arrhythmias, and heart blocks, which frequently require cardiac device implantation (CDI). However, the differences between light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis CDI requirements are unknown. Methods A retrospective analysis was conducted using the
Bilal Hussain, Sanchit Duhan, Khawaja Hassan Akhtar, Amith Reddy Seri, Krittapoom Akrawinthawong, Janardhana Gorthi, Bijeta Keisham, Tarun Dasari   +7 more
wiley   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Amyloidosis presenting as bilateral transudative pleural effusions with normal cardiac investigations: a case report [PDF]

, 2009
A 66-year-old man with a diagnosis of monoclonal gammopathy of unknown significance was referred for investigation of bilateral transudative pleural effusions by the cardiology team.
James H Briggs, William G Singleton, Margaret M Burke, Lorraine A Hart, Robert J Parker   +4 more
core   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

High‐throughput monoclonal gammopathy community monitoring programme

British Journal of Haematology, EarlyView.
Gaurav Agarwal, Lauren Campbell, Oluremi Carty, Jemma Larham, Elizabeth Knight, Sally Moore, Sarah Gooding, Jaimal Kothari, Joe Browning, Julia Evans, Lisa Ferguson, Ana Vieira, Liam Swanborough, Pamela Roberts, Elizabeth Bateman, Ross Sadler, Karthik Ramasamy   +16 more
wiley   +1 more source

Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases

Aggregate, Volume 7, Issue 3, March 2026.
Amyloid‐ID, a ThT‐like photocatalytic probe, enables proteotyping of amyloid deposits by ROS‐mediated protein labeling. Applied to patient biopsies, amyloid‐ID identifies potential fibrinogen‐derived amyloid in laryngeal amyloidosis, revealing a mechanically sensitive fibrillation mechanism linked to vocal cord friction.
Huan Feng, Fangliang Guo, Yan Wang, Meng You, Qiuxuan Xia, Wang Wan, Di Shen, Kaini Shen, Xin Zhang, Wei Li, Yu Liu   +10 more
wiley   +1 more source

Obstructive sleep apnea severity, Alzheimer's disease plasma markers, and CSF brain amyloidosis and tau pathology

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION We examined obstructive sleep apnea (OSA) severity's association with Alzheimer's disease (AD) plasma biomarkers, independent or synergistic with cerebrospinal fluid (CSF) amyloid, and as a proof of concept, whether plasma amyloid beta (Aβ)42/Aβ40 with OSA severity improves detection of amyloidosis and tau pathology.
Omonigho Michael Bubu, Anna E. Mullins, Shreshtha Shah, Joshua L. Gills, Korey Kam, Ankit Parekh, Ogie Q. Umasabor‐Bubu, Arlener D. Turner, Mark Bernard, Anthony Briggs, Jaime Ramos‐Cejudo, Elena Valkanova, Alfred K. Mbah, Purbanka Pahari, Ludovic Debure, Mobeena Ghuman, Allal Boutajangout, Natasha J. Williams, Jeongyeon Hwang, Masrai K. Williams, David M. Rapoport, Indu Ayappa, Mony de Léon, Girardin Jean‐Louis, Andrew W. Varga, Ricardo S. Osorio   +25 more
wiley   +1 more source

Renal amyloidosis revisited: amyloid distribution, dynamics and biochemical type [PDF]

, 2017
Background. Renal amyloidosis results from protein misfolding and leads to progressive renal insufficiency. Few data are available concerning the relevance of the histomorphological patterns and the dynamics of the disease process. Methods.
Hopfer, Helmut, Mihatsch, Michael J., Wiech, Thorsten   +2 more
core  

Detection of vascular amyloid deposits in a bone marrow aspirate

British Journal of Haematology, EarlyView.
Konstantinos Liapis, Georgios Kanellis, Georgios Vrachiolias, Evangelia Charitaki   +3 more
wiley   +1 more source

Negative [99mTc]Tc ‐DPD Scintigraphy, Presence of Monoclonal Protein and Biopsy Suggestive of AL Amyloidosis in a Patient With Homozygous p.Ala101Val Transthyretin Gene Variant

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Amyloidosis is a rare disease associated with the deposition of misfolded proteins that damage multiple organs, leading to a wide range of symptoms. The most frequently implicated proteins in amyloidosis include immunoglobulin Free Light Chains (FLC), related to AL amyloidosis, and transthyretin (TTR), which is responsible for ATTR amyloidosis.
Paulina Kryszpin, Piotr Jachimowski, Łukasz Augustowski, Mateusz Ziarkiewicz, Grzegorz Basak, Marta Lipowska, Marta Legatowicz‐Koprowska, Bogna Ziarkiewicz‐Wróblewska, Monika Gawor‐Prokopczyk   +8 more
wiley   +1 more source