Results 121 to 130 of about 34,251 (240)

Outcomes Among MM Patients Receiving Early Intervention for MRD Progression Following Autologous Stem Cell Transplantation

Cancer Medicine, Volume 15, Issue 5, May 2026.
1. Some patients experience MRD progression (MRD‐P) before clinical or biochemical progression (PD), highlighting the value of MRD monitoring for the early detection of relapse. 2. Early intervention upon MRD progression in multiple myeloma patients was associated with improved survival outcomes and higher rates of MRD re‐negativity.
Xiaozhe Li, Meilan Chen, Lifen Kuang, Junru Liu, Beihui Huang, Juan Li   +5 more
wiley   +1 more source

Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis

Case Reports in Nephrology, 2012
AL amyloidosis complicating monoclonal gammopathy of undetermined significance (MGUS) has usually a predominant glomerular deposition of lambda light chain. Heavy proteinuria is one of its cardinal manifestations.
Yijuan Sun, Amarpreet Sandhu, Darlene Gabaldon, Jonathan Danaraj, Karen S. Servilla, Antonios H. Tzamaloukas   +5 more
doaj   +1 more source

Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis [PDF]

, 2018
Introduction: Renal biopsy series from North America suggest that leucocyte chemotactic factor 2 (ALECT2) amyloid is the third most common type of renal amyloid. We report the first case series from a European Centre of prevalence, clinical presentation
Bass, P, Fontana, M, Gilbertson, JA, Gillmore, JD, Hawkins, PN, Lachmann, HJ, Mahmood, S, Rendell, N, Rezk, T, Rowczenio, D, Sachchithanantham, S, Taylor, GW, Wechalekar, AD, Whelan, CJ, Wong, J   +14 more
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Multiple Myeloma Presenting as Lower Gastrointestinal Bleeding: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Multiple myeloma (MM) is a malignant hematologic neoplasm that primarily affects the bone marrow and can invade other organs, leading to diverse clinical manifestations. Presentation with gastrointestinal bleeding as the initial symptom is exceptionally rare.
Ahmed Arabi, Naseem Ambra, Asgad Mohamed Ahmed Eltigani, Asma Ahmed Yousif, Abdelkarim Hashim Mohamed   +4 more
wiley   +1 more source

PLA2R‐Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Betelhem Abreham, Leja Hamza, Azeb Kebede, Daniel Rebuma Bekele, Zekarias Amdemariam   +4 more
wiley   +1 more source

Induced Circular Dichroism From the Binding of Achiral Bivalent Ligands to Transthyretin

Journal of Molecular Recognition, Volume 39, Issue 3, May 2026.
ABSTRACT Achiral bivalent ligands capable of simultaneous occupation of both hormone binding sites of transthyretin generate a substantial and complex induced near ultraviolet circular dichroism spectrum during protein binding, revealing the dynamics of this process.
Stephen Wood, Yiwei Guan, James Pitts, Raj Gill, Simon Kolstoe, Támas Jávorfi, Rohanah Hussain, Giuliano Siligardi   +7 more
wiley   +1 more source

Systemic Light Chain Amyloidosis

New England Journal of Medicine
Minnema M, Schönland S.
europepmc   +6 more sources

Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements [PDF]

, 2011
Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein.
Chellappah Thambiah, Subashini, George, Elizabeth, Umar, Nor Aini   +2 more
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Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Renal amyloidosis revisited: amyloid distribution, dynamics and biochemical type [PDF]

, 2017
Background. Renal amyloidosis results from protein misfolding and leads to progressive renal insufficiency. Few data are available concerning the relevance of the histomorphological patterns and the dynamics of the disease process. Methods.
Hopfer, Helmut, Mihatsch, Michael J., Wiech, Thorsten   +2 more
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