Results 121 to 130 of about 4,786,755 (237)

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

CRISPR‐Cas9 and precision editing technologies linking functional genomics to clinical translation in genetic diseases

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRISPR‐Cas9 and precision editing technologies enable a variant‐mechanism‐driven framework for genetic disease research and therapeutic development. Pathogenic variants are first interpreted according to mutation type, coding or regulatory consequence, tissue context, and disease mechanism.
Zijing Wen, Jianming Su
wiley   +1 more source

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

Glia, Volume 74, Issue 9, September 2026.
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko, Shu‐Hui Chu, Angela Gomez‐Arboledas, Blossom Zhang, Andrea J. Tenner   +4 more
wiley   +1 more source

Clonotypic characterization defines B‐cell drivers of clonal expansion and intratumor heterogeneity in IgM monoclonal gammopathies

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Waldenström macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (MGUS) share the same cell of origin but differ in clonal size. Compared with other B‐cell neoplasms, the lymphoplasmacytic clone in WM can be rather small, limiting our understanding of clonal expansion.
David F. Moreno, Ferran Nadeu, Marta Casado‐Peláez, Caterina Mata, Ian Márquez‐López, Marco A. Fernández, Sergi Vaqué, Elena Medina, Helena Llobregat, Marta Garrote, Joan Mañé, Oriol Cardús, Luis Gerardo Rodríguez‐Lobato, Anna de Daniel, María Teresa Cibeira, Theo Gremen Oliveira, Elizaveta Kulaeva, Ester Lozano, Dolors Colomer, Laura Rosiñol, Ruben van Boxtel, Manel Esteller, Carlos Fernández de Larrea   +22 more
wiley   +1 more source

Bilateral atrial appendage thrombosis in light chain cardiac amyloidosis: a case report

Frontiers in Cardiovascular Medicine
Light chain cardiac amyloidosis (AL-CA) is a severe and progressively infiltrative disease caused by the deposition of misfolded monoclonal immunoglobulin light chains in the myocardial extracellular space.
Haiyan Jia, Shengqi Jia, Weifeng Zhang, Zepeng Ma, Xiaomin Meng   +4 more
doaj   +1 more source

Dynamic risk stratification in smoldering multiple myeloma: Integrating evolving biomarkers with the 2/20/20 Model

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Smoldering multiple myeloma (SMM) is a heterogeneous precursor with variable risk of progression to multiple myeloma (MM). Current risk models rely on baseline features, limiting predictive accuracy. We aimed to define evolving risk factors and integrate them with the 2/20/20 model to improve risk stratification.
Theresia Akhlaghi, David Nemirovsky, Kylee H. Maclachlan, Ross S. Firestone, Neha Korde, Sham Mailankody, Alexander M. Lesokhin, Hani Hassoun, Dhwani Patel, Urvi A. Shah, Carlyn R. Tan, Heather J. Landau, Gunjan L. Shah, Michael Scordo, Anish K. Simhal, Ola Landgren, Sergio A. Giralt, Saad Z. Usmani, Andriy Derkach, Malin Hultcrantz   +19 more
wiley   +1 more source

Management of Refractory and Difficult‐To‐Treat Inflammatory Bowel Disease: An Expert Opinion Review

JCC Plus, Volume 1, Issue 5, September 2026.
This expert opinion offers a practical framework for refractory and difficult‐to‐treat IBD: confirm inflammation objectively, distinguish pharmacologic from structural and functional disease, and then escalate. Across ten clinical questions, the evidence is often limited to case series, and the resulting statements are identified as expert opinion ...
Filiz Akyuz, Oguz Kagan Bakkaloglu, Nalan Gulsen Unal, Ismail Hakki Kalkan, Mehmet Arhan, Ibrahim Hatemi, Taylan Kav, Murat Toruner, Hale Akpinar, Ahmet Tezel, Aykut Ferhat Celik   +10 more
wiley   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Primary Localized Cutaneous Amyloidosis: A Histological and Immunohistochemical Appraisal

Indian Dermatology Online Journal
Background: Primary localized cutaneous amyloidosis (PLCA) is a rare chronic heterogeneous group of disorders with deposition of abnormally folded beta-pleated protein in the dermo-epidermal junction and dermis.
Nithye Parvathy, Rashmi Joshi, Rajsmita Bhattacharjee, Uma N. Saikia, Dipankar De, Debajyoti Chatterjee   +5 more
doaj   +1 more source