Results 111 to 120 of about 4,786,755 (237)

Systemic Light Chain Amyloidosis [PDF]

, 2018
AbstractSystemic light chain (AL) amyloidosis is a rare protein misfolding and deposition disorder. Clonal plasma cells or rarely B cells produce immunoglobulin light chains with the potential to misfold. Treatment is clone directed with the goal to achieve a complete or at least very good hematological remission.
Monique Minnema, Stefan Schönland
openaire   +1 more source

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Lnk, H., Gratzl, Manfred   +5 more
core   +1 more source

MCH‐Guard: Multimodal machine learning framework for risk stratification of cerebral microhemorrhage risk in the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Efficient cerebral microhemorrhage (MCH) monitoring is critical for anti‐amyloid therapy safety due to amyloid‐related imaging abnormalities with hemosiderin deposition (ARIA‐H) risk. We developed MCH‐Guard, a multimodal machine‐learning framework, to stratify MCH risk for Alzheimer's Disease Neuroimaging Initiaitive (ADNI ...
Alper Gel, Eliana Phillips, Isabella Hausle, Pamela Thropp, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +5 more
wiley   +1 more source

Diagnosing Light Chain Amyloidosis on Temporal Artery Biopsies for Suspected Giant Cell Arteritis

, 2017
Although still rarely diagnosed, amyloid light chain (AL) amyloidosis is the most common form of systemic amyloidosis. It is characterized by misfolded monoclonal immunoglobulin light chain fragments that accumulate extracellularly as amyloid fibrils ...
Rosanna A. M. Ghinai; Shameem Mahmood; Pinias Mukonoweshuro; Sally Webber; Ashutosh D. Wechalekar; Sally E. Moore
core  

Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION We investigated the synergistic effects of comorbid insomnia and anxiety on cognitive impairment and dementia and explored the underlying plasma biomarker mechanisms. METHODS We included adults ≥ 60 years from the cross‐sectional cohort named The Shanghai Action to Prevent Dementia in the Elderly (SHAPE) and used data from the ...
Yan Chen, Qianxi Wang, Ling Li, Shixing Qian, Li Bai, Tih Shih Lee, Shaowei Zhang, Yaping Li, Qianqian Guo, Yang Yang, Feng Yan, Lei Feng, Xia Li   +12 more
wiley   +1 more source

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Microglia‐mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer's disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood. METHODS We assessed AD‐related phenotypes in 5xFAD mice with microglia‐specific deletion of transmembrane protein 59 (TMEM59 ...
Jian Meng, Yong Wang, Jinghui Wang, Yiqing Chen, Zihao Zhao, Ziqian Tang, Jing Cao, Xian Zhang, Hong Luo, Huihui Li, Yili Wu, Yingjun Zhao, Weihong Song, Yun‐wu Zhang   +13 more
wiley   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1961-1974, September 2026.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics

Haematologica, 2014
Examination of abdominal subcutaneous fat aspirates is a practical, sensitive and specific method for the diagnosis of systemic amyloidosis. Here we describe the development and implementation of a clinical assay using mass spectrometry-based proteomics ...
Julie A. Vrana, Jason D. Theis, Surendra Dasari, Oana M. Mereuta, Angela Dispenzieri, Steven R. Zeldenrust, Morie A. Gertz, Paul J. Kurtin, Karen L. Grogg, Ahmet Dogan   +9 more
doaj   +1 more source

A Multivariable Prediction Model for Early Mortality in Multiple Myeloma Patients With Renal Impairment

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Despite therapeutic advances, early mortality remains a significant challenge in multiple myeloma (MM) patients with renal impairment (RI), with no validated prognostic models currently available for this high‐risk subgroup. This multicenter, retrospective study aimed to develop and validate a practical nomogram for predicting early death ...
Menghan Liu, Yuan Jian, Huixing Zhou, Jing Jia, Jiachen Li, Chuanying Geng, Guangzhong Yang, Wenrong Huang, Xinan Cen, Wenming Chen, Honghu Zhu, Wen Gao   +11 more
wiley   +1 more source