Results 131 to 140 of about 4,786,755 (237)

Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity

MedComm, Volume 7, Issue 9, September 2026.
This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu, Yixuan Sheng, Yun Chang, Yuan Chang, Miaomiao Xu, Wenjing Zhou, Wenxiu Wang, Qingyuan Liao, Zhan Shi, Meng Zhang, Feng Lan, Jiangping Song, Xiaoyan Qiu   +12 more
wiley   +1 more source

Gradually Enlarging Nodular Pulmonary Amyloidosis Associated With Sjögren's Syndrome

Respirology Case Reports, Volume 14, Issue 9, September 2026.
A woman with Sjögren's syndrome presented with progressively enlarging pulmonary nodules showing calcification and cystic changes, mimicking metastatic malignancy. Histological examination confirmed AL λ‐type nodular pulmonary amyloidosis. Recognition of this radiological pattern is important to avoid misdiagnosis and unnecessary invasive interventions.
Noboru Morikawa, Satoshi Mikami, Daisuke Suzuki   +2 more
wiley   +1 more source

Predicting Structural Consequences of Antibody Light Chain N-Glycosylation in AL Amyloidosis

Pharmaceuticals
Background/Objectives: Antibody light chains form amyloid fibrils that lead to progressive tissue damage in amyloid light chain (AL) amyloidosis. The properties of each patient’s unique light chain appear to determine its propensity to form amyloid.
Gareth J. Morgan, Zach Yung, Brian H. Spencer, Vaishali Sanchorawala, Tatiana Prokaeva   +4 more
doaj   +1 more source

Pulmonary Amyloidosis Diagnosed by Transbronchial Lung Biopsy: A Three‐Case Series With Diverse Radiological Manifestations

Respirology Case Reports, Volume 14, Issue 9, September 2026.
Pulmonary amyloidosis presents with diverse radiological manifestations ranging from nodular lesions to diffuse interstitial abnormalities. Conventional forceps TBLB may serve different clinical roles according to disease presentation: distinguishing localized nodular amyloidosis from malignancy and providing an initial diagnostic clue to systemic ...
Masaki Tanaka, Yuri Ozaki, Takuo Otsuka, Takahide Hongo, Mari Tone, Yuhei Kinehara, Shoichi Ihara, Yoshito Takeda, Ryu Jokoji, Isao Tachibana   +9 more
wiley   +1 more source

Pulmonary AL Amyloidosis as a Cause of Interstitial Lung Disease Diagnosed With Transbronchial Lung Biopsy

Respirology Case Reports, Volume 14, Issue 9, September 2026.
Importance of tissue diagnosis in pulmonary amyloidosis, a rare albeit treatable cause of interstitial lung disease. ABSTRACT Pulmonary amyloidosis is a rare manifestation of amyloid deposition which can present as a rare albeit treatable cause of interstitial lung disease.
Kai Wen Hwang, Ju Ee Seet, Michelle Poon, Kay Choong See   +3 more
wiley   +1 more source

Hepatic amyloidosis with light chain deposition disease. A rare association.

, 2000
Monoclonal immunoglobulin deposition diseases are due to pathological protein deposition in various tissues and organs. Protein deposits may be found in a single tissue or systemically and the organs most frequently involved are kidney, heart, peripheral
De Paoli A, Lavazza MT, Gualdoni G, Beretta R., Casiraghi MA, Assi A, PALLADINI, GIOVANNI, Beretta A   +7 more
core   +1 more source

Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels

Aging Cell, Volume 25, Issue 9, September 2026.
The identification of the glymphatic system (GS) and meningeal lymphatic vessels (mLVs) challenges the century‐old “immune‐privileged” dogma of the central nervous system (CNS), establishing a critical mechanistic link between impaired waste clearance (Aβ/tau) and the pathogenesis of Alzheimer's disease (AD).
Bingbing Song, Wei Wang, Siqi Liu, Xi Jin, Yan Qi, Mingquan Li, Dongjie Yue, Yu Liu, Xiangqi Li, Lei Yin, Lina Feng   +10 more
wiley   +1 more source

Systemic light-chain amyloidosis presenting with rapid progressive heart failure

, 2013
Systemic amyloid light-chain (AL) amyloidosis is caused by deposition of immunoglobulin light-chain proteins. AL amyloidosis is a rapidly progressive disease that affects multiple organs. Cardiac involvement is frequent (50%) and the median survival is 5
SÜNBÜL, MURAT, MUTLU, BÜLENT, SARI, İBRAHİM   +2 more
core   +1 more source

Management and long‐term haematological and neurological outcomes of Immunoglobulin M and Waldenström's macroglobulinaemia‐related neuropathy: A single‐centre experience

British Journal of Haematology, Volume 209, Issue 3, Page 1031-1038, September 2026.
In this 28‐patient retrospective cohort, rituximab‐based regimens for IgM‐related neuropathy yielded significant, sustained functional and neurological improvements over a 2‐year follow‐up. Furthermore, reductions in serum IgM levels correlated with improved Inflammatory Neuropathy Cause and Treatment disability scores, highlighting the long‐term ...
Maria Gavriatopoulou, Ioannis Ntanasis‐Stathopoulos, Charalampos Filippatos, Panagiotis Malandrakis, Sotirios Manganas, Foteini Theodorakakou, Irene Solia, Evangelos Eleutherakis‐Papaiakovou, Ilias Katsadouros, Panagiotis Boutsikos, Despina Fotiou, Magdalini Migkou, Nikolaos Kanellias, Evangelos Terpos, Efstathios Kastritis, Meletios‐Athanasios Dimopoulos   +15 more
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, Volume 59, Issue 9, September 2026.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source