Results 31 to 40 of about 35,531 (245)

Localized Lymph Node Light Chain Amyloidosis

Case Reports in Hematology, 2015
Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and ...
Binod Dhakal, Alexandra M. Harrington, Michael E. Stadler, Anita D’Souza   +3 more
doaj   +1 more source

Light‐chain amyloid myopathy isolated to skeletal muscles: A case report

Clinical Case Reports, 2020
Isolated amyloidosis, especially of amyloid light‐chain type, is an infrequent disease. Systemic chemotherapy for light‐chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin.
Toshihiro Matsukawa, Katsuki Eguchi, Ichizo Nishino, Kohei Okada, Kazuo Oshimi, Takuto Miyagishima   +5 more
doaj   +1 more source

Duodenal biopsy: an unexpected confirmatory test for a patient with al-amyloidosis

Sri Lanka Journal of Medicine, 2019
SSystemic AL- amyloidosis is a disorder of protein folding in which there is extra-cellular accumulation as β pleated fibrillar deposits of monoclonal immunoglobulin light chain fragments. AL- amyloidosis is a rare clinical entity.
S. Pirasath, T. Kumanan, G. Selvaratnam, V. Sujanitha, D. D. Dikowita   +4 more
doaj   +1 more source

Syndrome in Question [PDF]

Anais Brasileiros de Dermatologia, 2015
Immunoglobulin light chain amyloidosis is the most common acquired systemic amyloidosis. Its presentation is often insidious and progressive, which may delay diagnosis.
Han MA, Meilan Chen, Juan Li, Ying Li, Shu Qiu   +4 more
doaj   +1 more source

Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis

Hemato, 2021
Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in ...
Gareth J. Morgan, Joel N. Buxbaum, Jeffery W. Kelly   +2 more
doaj   +1 more source

Evaluation of the N Latex free light chain assay in the diagnosis and monitoring of AL amyloidosis [PDF]

, 2013
Background: We compared a novel assay for free light chain (FLC) quantitation based on monoclonal antibodies (N-Latex, Siemens, Germany) to the established polyclonal antibody-based assay (Freelite (TM), The Binding Site, UK) in AL ...
Campbell, Campbell, Comenzo, Comenzo, Davern, Davern, Dispenzieri, Dispenzieri, Katzmann, Katzmann, Kumar, Kumar, Kumar, Kumar, Lachmann, Lachmann, Mollee, Mollee, Morris, Morris, Palladini, Palladini, Palladini, Palladini, Palladini, Palladini, Pretorius, Pretorius, Tate, Tate, Tate, Tate, Velthuis, Velthuis   +33 more
core   +1 more source

Natural history and outcome in systemic AA amyloidosis [PDF]

, 2007
BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders.
Gallimore, JR, Gilbertson, JA, Gillmore, JD, Goodman, HJB, Hawkins, PN, Lachmann, HJ, Sabin, CA   +6 more
core   +1 more source

Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome [PDF]

, 2013
Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types.
Banypersad, SM, Dungu, J, Gibbs, SD, Gilbertson, JA, Gillmore, JD, Hawkins, PN, Lachmann, HJ, McCarthy, CA, Petrie, A, Pinney, JH, Rowczenio, D, Sattianayagam, P, Venner, CP, Wassef, N, Wechalekar, A, Whelan, CJ   +15 more
core   +1 more source

Amyloidosis: a case series and review of the literature

Journal of Medical Case Reports, 2023
Background Systemic amyloidosis is group of disorders characterized by the accumulation of insoluble proteins in tissues. The most common form of systemic amyloidosis is light chain amyloidosis, which results from the accumulation of misfolded ...
Justin B. Senecal, Romel Abou-Akl, Pat Allevato, Ian Mazzetti, Caroline Hamm, Richa Parikh, Indryas Woldie   +6 more
doaj   +1 more source

C-src Enriched Serum Microvesicles Are Generated in Malignant Plasma Cell Dyscrasia [PDF]

, 2013
Plasma cell dyscrasias are immunosecretory disorders that can lead to hematological malignancies such as Multiple Myeloma (MM). MM accounts for 15% of all hematologic cancers, and those diagnosed with MM typically become severely ill and have a low life
Andrea, Zendrini, Caimi, Luigi, DI NOTO, Giuseppe, Paolini, Lucia, Radeghieri, Annalisa, Ricotta, Doris   +5 more
core   +8 more sources