Results 21 to 30 of about 19,748 (182)

How I manage systemic light chain amyloidosis

Hematology Reports, 2021
Light chain amyloidosis (AL) is a protein deposition disorder with a heterogenous pattern of organ involvement and dysfunction that varies by affected patient.
Gregory P. Kaufman, Claudio Cerchione
doaj   +1 more source

Biomarkers in Immunoglobulin Light Chain Amyloidosis

Klinicka Onkologie, 2017
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction.
Kufova, Z., Sevcikova, T., Growkova, K., Vojta, P., Filipova, J., Adam, Z., Pour, L., Penka, M., Rysava, R., Nemec, P., Brozova, L., Vychytilova, P., Jurczyszyn, Artur, Grosicki, S., Barchnicka, A., Hajduch, M., Simicek, M., Hajek, R.   +17 more
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Immunoglobulin light chain amyloidosis [PDF]

memo - Magazine of European Medical Oncology, 2021
SummaryImmunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed life-threatening systemic disease, primarily caused by insoluble depositions of misfolded monoclonal light chains. The monoclonal light chain paraprotein originates from a small clonal B‑cell or a clonal plasma cell population.
Hermine Agis, Maria T. Krauth
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Systemic Light Chain Amyloidosis

New England Journal of Medicine
Systemic light chain (AL) amyloidosis is a rare protein misfolding and deposition disorder. Clonal plasma cells or rarely B cells produce immunoglobulin light chains with the potential to misfold. Treatment is clone directed with the goal to achieve a complete or at least very good hematological remission.
Maurizio, Marvisi, Sara, Ramponi
  +8 more sources

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Nature Communications, 2019
Immunoglobulin Light Chain Amyloidosis (AL) is the most common systemic amyloidosis occurring in Western countries. Here the authors present the 4.0 Å cryo-EM structure of light chain AL55 fibrils that were isolated from the heart of an AL systemic ...
Paolo Swuec, Francesca Lavatelli, Masayoshi Tasaki, Cristina Paissoni, Paola Rognoni, Martina Maritan, Francesca Brambilla, Paolo Milani, Pierluigi Mauri, Carlo Camilloni, Giovanni Palladini, Giampaolo Merlini, Stefano Ricagno, Martino Bolognesi   +13 more
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Localized Immunoglobulin Light-Chain Amyloidosis of the Ulnar Nerve

Case Reports in Neurology, 2021
Amyloidosis is a disorder caused by extracellular tissue deposition of insoluble fibrils. Amyloidosis can be divided into systemic or localized disease. Primary systemic amyloidosis is a multisystem disease caused by the deposition of amyloid in various ...
Shinsuke Morisaki, Shinji Tsuchida, Eiichi Konishi, Nagaaki Katoh, Yusuke Takahashi, Kenji Takahashi   +5 more
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Idiopathic membranous nephropathy with renal amyloidosis: A case report

Frontiers in Medicine, 2022
BackgroundImmunoglobulin light chain amyloidosis is a clonal, non-proliferative plasma cell disorder, in which fragments of immunoglobulin light chain are deposited in tissues.
Yue Wang, Xueyao Wang, Jinyu Yu, Shan Wu, Zhonggao Xu, Weixia Sun   +5 more
doaj   +1 more source

Bortezomib, Melphalan, and Dexamethasone for Light-Chain Amyloidosis [PDF]

Journal of Clinical Oncology, 2020
PURPOSE Oral melphalan and dexamethasone (MDex) were considered a standard of care in light-chain (AL) amyloidosis. In the past decade, bortezomib has been increasingly used in combination with alkylating agents and dexamethasone. We prospectively compared the efficacy and safety of MDex and MDex with the addition of bortezomib (BMDex).
Kastritis, Efstathios, Leleu, Xavier, Arnulf, Bertrand, Zamagni, Elena, Cibeira, Maria Teresa, Kwok, Fiona, Mollee, Peter, Hajek, Roman, Moreau, Philippe, Jaccard, Arnaud, Schonland, Stefan O., Filshie, Robin, Nicolas-Virelizier, Emmanuelle, Augustson, Bradley, Mateos, Maria-Victoria, Wechalekar, Ashutosh, Hachulla, Eric, Milani, Paolo, Dimopoulos, Meletios A., Fermand, Jean-Paul, Foli, Andrea, Gavriatopoulou, Maria, Klersy, Catherine, Palumbo, Antonio, Sonneveld, Pieter, Johnsen, Hans Erik, Merlini, Giampaolo, Palladini, Giovanni   +27 more
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Immunoglobulin light chain amyloidosis and the kidney [PDF]

Kidney International, 2002
Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Gertz, Morie A., Lacy, Martha Q., Dispenzieri, Angela   +2 more
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Localized Lymph Node Light Chain Amyloidosis

Case Reports in Hematology, 2015
Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and ...
Binod Dhakal, Alexandra M. Harrington, Michael E. Stadler, Anita D’Souza   +3 more
doaj   +1 more source