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Diagnosis for Chinese patients with light chain amyloidosis: a scoping review
Annals of Medicine, 2023 Background Amyloid light chain (AL) amyloidosis is the most common systemic amyloidosis. The objective of this scoping review was to map the available literature on the diagnosis of AL amyloidosis in China.Materials and Methods The published academic ...
Meilan Chen +9 more
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Light-Chain Amyloidosis: The Great Impostor
Life, 2023 Light-chain amyloidosis (AL) is a disease of protean manifestations due to a wide spectrum of organs that can be affected. The disorder is caused by the deposition of an extracellular amorphous material, the amyloid, which is produced by malignant plasma cells.
Georgia Stefani +2 more
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Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021
Blood Cancer Journal, 2021 Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients ...
M. Hasib Sidiqi, Morie A. Gertz
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Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
Haematologica, 2013 Amyloidosis of the gastrointestinal tract, with biopsy-proven disease, is rare. We reviewed a series of patients who presented with biopsy-proven gastrointestinal amyloidosis and report their clinical characteristics, treatments, and survival.
Andrew J. Cowan +7 more
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Biomarkers in Immunoglobulin Light Chain Amyloidosis
Klinicka Onkologie, 2017 Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction.
Kufova, Z. +17 more
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Novel Therapies in Light Chain Amyloidosis [PDF]
Kidney International Reports, 2018 Light chain (AL) amyloidosis is the most common form of amyloidosis involving the kidney. It is characterized by albuminuria, progressing to overt nephrotic syndrome and eventually end-stage renal failure if diagnosed late or ineffectively treated, and in most cases by concomitant heart involvement.
Milani P., Merlini G., Palladini G.
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How I manage systemic light chain amyloidosis
Hematology Reports, 2021 Light chain amyloidosis (AL) is a protein deposition disorder with a heterogenous pattern of organ involvement and dysfunction that varies by affected patient.
Gregory P. Kaufman, Claudio Cerchione
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Concurrent Presentation of Light Chain Amyloidosis and Renal Cell Carcinoma in an Elderly Male : A Case Report and Review of the Literature [PDF]
, 2023 Amyloidosis is often known as “the great imitator,” as the clinical diagnosis of AL amyloidosis is quite challenging and often delayed, given multi-organ involvement.
Amol Joshi, Meron Dinsa, Hien Nguyen
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Hellenic Journal of Cardiology, 2019 Objective: Light-chain amyloidosis and transthyretin-related amyloidosis (wild-type and mutated) are three main types of systemic amyloidosis associated with a clinically relevant cardiac involvement. In this study, we compared prognosis in patients with
Yanguo Xin +5 more
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Nature Communications, 2019 Immunoglobulin Light Chain Amyloidosis (AL) is the most common systemic amyloidosis occurring in Western countries. Here the authors present the 4.0 Å cryo-EM structure of light chain AL55 fibrils that were isolated from the heart of an AL systemic ...
Paolo Swuec +13 more
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