Results 101 to 110 of about 598,532 (267)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Photometric Study of Extreme Long Period Eclipsing Binary 31 CYG [PDF]
Journal of Astronomy and Space Sciences, 1991 The UBV light curves of an extreme long period binary star 31 Cyg are made with the observations obtained at Yonsei University Observatory for three seasons from 1988 to 1991 and the RI light curves are also made for one season in 1990-1991.
Jang Hae Jeong, Yong-Sam Lee, Ho-Il Kim
doaj
Impact of Pulsation Activity on the Light Curves of Symbiotic Variables [PDF]
, 2015 V. I. Marsakova +4 more
openalex +1 more source
Supernova Neutrino Light Curves from Cooling of High/Low-Mass Proto-Neutron Stars
, 2021 Ken’ichiro Nakazato +1 more
openalex +2 more sources
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Typical X-Ray Outburst Light Curves of Aql X-1
The Astrophysical JournalWe show that the typical X-ray outburst light curve of Aql X-1 can be reproduced by accretion onto a neutron star in the frame of the disk instability model without invoking partial accretion or the propeller effect.
Ömer Faruk Çoban, Ünal Ertan
doaj +1 more source
Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins
FEBS Open Bio, EarlyView.We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó +7 more
wiley +1 more source
Classification of Exoplanetary Light Curves Using Artificial Intelligence
AIIn this article, we propose a robust star classification methodology leveraging light curves collected from 15 datasets within the Kepler field in the visible optical spectrum.
Leticia Flores-Pulido +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source
New Rotation Periods from the Kepler Bonus Background Light Curves
The Astrophysical JournalThe Kepler field hosts the best-studied sample of field star rotation periods. However, due to Kepler’s large 4″ pixels, many of its light curves are at high risk of contamination from background sources.
Zachary R. Claytor, Jamie Tayar
doaj +1 more source