Results 91 to 100 of about 636,094 (261)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Hydrogen-poor Superluminous Supernovae with Bumpy Light Curves Powered by Precessing Magnetars

The Astrophysical Journal
Recent observations and statistical studies have revealed that a significant fraction of hydrogen-poor superluminous supernovae (SLSNe-I) exhibit light curves that deviate from the smooth evolution predicted by the magnetar-powered model, instead showing
Biao Zhang, Long Li, Zi-Gao Dai, Shu-Qing Zhong   +3 more
doaj   +1 more source

Photoelectric Observations and Analysis of the Contact Binary W UMa [PDF]

Journal of Astronomy and Space Sciences, 2001
The unpublished photoelectric observations of the contact binary W UMa in ultraviolet, blue, and yellow bandpasses made on four nights during the observing seasons from April, 1984 to May, 1985 were presented.
Chun-Hwey Kim, Chung Uk Lee, Young Woon Kang   +2 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

BLADE: An Automated Framework for Classifying Light Curves from the Center for Near-Earth Object Studies Fireball Database

The Astronomical Journal
Fireballs (bolides) are high-energy luminous phenomena produced when meteoroids and small asteroids enter Earth’s atmosphere at hypersonic speeds, often resulting in fragmentation or complete disintegration accompanied by significant energy release.
Elizabeth A. Silber, Vedant Sawal
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Physics-driven Explosions of Stripped High-mass Stars: Synthetic Light Curves and Spectra of Stripped-envelope Supernovae with Broad Light Curves

The Astrophysical Journal
Stripped-envelope supernovae (SESNe) represent a significant fraction of core-collapse supernovae, arising from massive stars that have shed their hydrogen and, in some cases, helium envelopes. The origins and explosion mechanisms of SESNe remain a topic
Jing Lu, Brandon L. Barker, Jared Goldberg, Wolfgang E. Kerzendorf, Maryam Modjaz, Sean M. Couch, Joshua V. Shields, Andrew G. Fullard   +7 more
doaj   +1 more source

Photometric and Radial Velocity Curves Analyses of the Triple System τ Tauri [PDF]

Journal of Astronomy and Space Sciences, 1995
New UBVRI observations of triple star τ Tau were at Chungbuk National University Observatory for 31 nights from Dec. 1990 to Jan. 1994. A total of 2930 photometric observations were obtained with 586 points for each filters, and BVRI light curves were ...
Yong-Sam Lee, Su-Jin Kwon
doaj