Results 111 to 120 of about 5,682 (253)
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Current topics in signal transduction in bacteria
, 1998 Among the signal transfer systems in bacteria two types predominate: two-component regulatory systems and quorum sensing systems. Both types of system can mediate signal transfer across the bacterial cell envelope; however, the signalling molecule ...
Kort, R +12 more
core +1 more source
A novel computer simulation method for simulating the multiscale transduction dynamics of signal proteins [PDF]
, 2012 Signal proteins are able to adapt their response to a change in the environment, governing in this way a broad variety of important cellular processes in living systems.
Bernhard Dick +6 more
core +1 more source
The signalling conformation of the insulin receptor ectodomain
Nature Communications, 2018 The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete.
Felix Weis +10 more
doaj +1 more source
Through the eyes of a pathogen: light perception and signal transduction in Acinetobacter baumannii
Photochemical & Photobiological Sciences, 2019 Sunlight is a ubiquitous environmental stimulus for the great majority of living organisms on Earth; therefore it is logical to expect the development of "seeing mechanisms" which lead them to successfully adapt to particular ecological niches. Although these mechanisms were recognized in photosynthetic organisms, it was not until recent years that the
Pezza, Alejandro +5 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
The D-ring, Not the A-ring, Rotates in Synechococcus OS-B' Phytochrome
, 2014 Phytochrome photoreceptors in plants and microorganisms switch photochromically between two states, controlling numerous important biological processes.
Psakis, Georgios +6 more
core +1 more source
Light-Controlled Growth Factor-Mediated Signal Transduction [PDF]
Biophysical Journal, 2015 Growth factor-mediated signal transduction regulates critical cellular responses including cell proliferation, differentiation, migration, and apoptosis. However, direct and quantitative linkage between time kinetics of growth factor-mediated pathways and the cellular response is still lacking due to difficulties in perturbing the kinetics of ...
openaire +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Role of Aggregation in Rhodopsin Signal Transduction
Many G protein-coupled receptors (GPCRs) are known to form dimers or even oligomers, and these aggregated states have been proposed as functional units responsible for signal transduction and G protein activation. However, the nature of their involvement
Vanni, Stefano +3 more
core +1 more source