Results 111 to 120 of about 938,065 (252)

The key piece of the airway remodeling puzzle revealed-LIGHT signaling in the lung. [PDF]

Genes Dis, 2023
Chen ZR, Hu J.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Editorial: Plant Phytochromes: From Structure to Signaling and Beyond

Frontiers in Plant Science, 2021
András Viczián, Cornelia Klose, Andreas Hiltbrunner, Andreas Hiltbrunner, Ferenc Nagy   +4 more
doaj   +1 more source

Dynamic LED spectral strategy enhances lettuce (Lactuca sativa) productivity via periodic activation of light-responsive genes and improved light energy use efficiency

Environmental and Experimental Botany
Artificial lighting in plant factories typically adopts a static, continuous spectral regime dominated by red light, with red-to-blue and red-to–far-red ratios generally maintained at approximately 3–6:1, resulting in limited exploration of dynamic light
Yanke Liu, Xinying Gao, Rong Ye, Zhanyi Li, Rongcheng Lin, Yang Li   +5 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Realigning the LIGHT signaling network to control dysregulated inflammation. [PDF]

J Exp Med, 2022
Ware CF, Croft M, Neil GA.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Light Signaling and Myopia Development: A Review. [PDF]

Ophthalmol Ther, 2022
Zhang P, Zhu H.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Light‐Based Juxtacrine Signaling Between Synthetic Cells

Small Science
Cell signaling through direct physical cell–cell contacts plays vital roles in biology during development, angiogenesis, and immune response. Intercellular communication mechanisms between synthetic cells constructed from the bottom up are majorly ...
Hossein Moghimianavval, Kyle J. Loi, Sung‐Won Hwang, Yashar Bashirzadeh, Allen P. Liu   +4 more
doaj   +1 more source