Results 51 to 60 of about 146,862 (339)

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

High-speed Video Observations on Abrupt Elongations of the Positive End of Bidirectional Leader

应用气象学报, 2020
One of the most important advances in lightning physics research in recent decades is the introduction of the the bidirectional developmengt of leaders and its observation and verification, but this theory is not paid much attention until more and more ...
Wu Bin, Lü Weitao, Qi Qi, Ma Ying, Chen Lüwen, Jiang Ruijiao   +5 more
doaj   +1 more source

Nowcasting lightning occurrence from commonly available meteorological parameters using machine learning techniques

npj Climate and Atmospheric Science, 2019
Lightning discharges in the atmosphere owe their existence to the combination of complex dynamic and microphysical processes. Knowledge discovery and data mining methods can be used for seeking characteristics of data and their teleconnections in complex
A. Mostajabi, D. Finney, M. Rubinstein, F. Rachidi   +3 more
semanticscholar   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Statistics and variability of the altitude of elves

Geophysical Research Letters, 2016
From June 2008 to January 2016 nearly 800 elves have been recorded by a low‐light camera in northeastern Spain. Elves occur in this region mainly over the lower topped cold air mass maritime thunderstorms, peaking from November to January.
Oscar A. van derVelde, Joan Montanyà
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Estimation of Lightning Activity of Squall Lines by Different Lightning Parameterization Schemes in the Weather Research and Forecasting Model

Remote Sensing, 2023
Based on three-dimensional lightning data and an S-band Doppler radar, a strong relationship was identified between lightning activity and the radar volume of squall lines. A detailed analysis of the squall line investigates the relationship following an
Dongxia Liu, Han Yu, Chunfa Sun
doaj   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Simulation of Cloud-to-Ground Lightning Strikes to Wind Turbines Considering Polarity Effect Based on an Improved Stochastic Lightning Model

Atmosphere, 2023
The accurate determination of the annual lightning flash number to a wind turbine is essential for designing proper lightning protection measures. However, the method to assess the lightning risk of wind turbines recommended by the IEC is not associated ...
Xiaoyan Bian, Yong Wu, Qibin Zhou, Ruijiao Jiang, Yao Zhang, Lyuwen Chen, Qi Qi, Weitao Lyu   +7 more
doaj   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source