Results 101 to 110 of about 4,069,627 (285)
Neural quasiprobabilistic likelihood ratio estimation with negatively weighted data
Machine Learning: Science and TechnologyMotivated by real-world situations found in high energy particle physics, we consider a generalization of the likelihood-ratio estimation task to a quasiprobabilistic setting where probability densities can be negative, and to importance sampling where ...
Matthew Drnevich +3 more
doaj +1 more source
"Empirical Likelihood Methods in Econometrics: Theory and Practice" [PDF]
Recent developments in empirical likelihood (EL) methods are reviewed. First, to put the method inperspective, two interpretations of empirical likelihood are presented, one as a nonparametric maximum likelihood estimation method (NPMLE) and the other as
Yuichi Kitamura
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Decomposition and convergence of likelihood ratios
Information and Control, 1980 The asymptotic behaviour of likelihood ratios is investigated by analyzing the two sequences obtained from Doob's decomposition of the log likelihood ratio sequence. Convergence of the likelihood ratio is implied by separate conditions on these sequences.
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
EMPIRICAL LIKELIHOOD ESTIMATORS OF THE LINEAR SIMULTANEOUS EQUATIONS MODEL [PDF]
Information theoretic estimators are specified for a system of linear simultaneous equations, including maximum empirical likelihood, maximum empirical exponential likelihood, and maximum log Euclidean likelihood.
Judge, George G. +2 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Are Relieving Maneuvers Useful in Diagnosis of Carpal Tunnel Syndrome?
The Turkish Journal of Gastroenterology, 2008 Objective: Our aim was to assess and compare the diagnostic accuracy of the carpal tunnel syndrome relief maneuver (CTS-RM) and the Flick sign for the diagnosis of carpal tunnel syndrome (CTS) in female patients.
Haydar Gok, Saime Ay, Sehim Kutlay
doaj
Scattergram of the positive likelihood ratio and negative likelihood ratio.
, 2013 Scattergram of the positive likelihood ratio and negative likelihood ratio.
Bin Li (39349) +4 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source