Results 91 to 100 of about 49,716 (300)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

In Silico Evaluation of Pharmacokinetics and Toxicity Profile of AlkaloidsPresent in Leaves of Catharanthus roseus L.

open access: yesRGUHS Journal of Pharmaceutical Sciences
Background Catharanthus roseus Madagascar periwinkle is a well-known medicinal plant that produces a variety of alkaloids with significant pharmacological activities particularly in cancer and diabetes treatment.Aim This study aimed ...
Ramgopal M Dhanwad, Usha R, Ganesh S
doaj   +1 more source

The Word Wolke—If It Is One

open access: yesStudies in 20th & 21st Century Literature, 1986
Walter Benjamin's theoretical linguistic considerations of the "Doctrine of Likeness" and the project "On the Mimetic Capacity'' were formulated in close—not only close in time—connection with the recording of Berlin Childhood Around Nineteen Hundred ...
Werner Hamacher
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Likeness, Familiarity, and the Ambient Portrait Average

open access: yes, 2020
© The Author(s) 2020. This artist-led research project involved 10 visual artists producing 10 ambient portraits and a portrait average of a locally familiar Sitter, and 10 ambient portraits and a portrait average of a less locally familiar Sitter.
Julie Telenta (8688903)   +11 more
core  

NaPLeS: a natural products likeness scorer—web application and database

open access: yesJournal of Cheminformatics, 2019
Natural products (NPs), often also referred to as secondary metabolites, are small molecules synthesised by living organisms. Natural products are of interest due to their bioactivity and in this context as starting points for the development of drugs ...
Maria Sorokina, Christoph Steinbeck
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Magidor-like and radin-like forcing

open access: yesAnnals of Pure and Applied Logic, 1983
Smith College, Northampton, MA 01063, USA Communicated by A. Nerode Received 15 April 1983 We force over a model M of ZF+ K + (K)
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Hooks with wax likeness

open access: yes, 2001
An image information sheet, featuring a photograph of Ben and Frances Hooks with a wax likeness of Ben during the annual NAACP ...

core  

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