Results 81 to 90 of about 49,716 (300)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Four heads are better than one: Combining face composites yields improvements in face likeness [PDF]

, 2002
Four participants constructed face composites, of familiar and unfamiliar targets, using Pro-Fit, with reference images present or from memory. The "mean" of all 4 composites, created by morphing (4-morph) was rated as a better likeness than individual ...
Rarity, Jenny, Hancock, Peter J B, Hayley Ness, Jenny Rarity, Ness, Hayley, Hancock, Peter J. B, Craig Newman, Newman, Craig, Hancock, Peter J. B., Peter J. B. Hancock, Vicki Bruce, Bruce, Vicki   +11 more
core   +1 more source

The Impact of Perceived Human Likeness of ChatGPT on Continuous Use Intention: The Mediating Effects of Perceived Benefits/Risks and the Moderated Mediation Effects of AI Literacy

SAGE Open
This study examined the impact of perceived human likeness (i.e., cognitive and affective) in ChatGPT on users’ perceived benefits (i.e., utilitarian and emotional benefits) and risks (i.e., privacy concerns and AI anxiety), as well as how these factors ...
Se Jung Kim, Sheng Ji Jin, Yongkuk Chung
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Towards a Harms Taxonomy of AI Likeness Generation [PDF]

Generative artificial intelligence models, when trained on a sufficient number of a person\u27s images, can replicate their identifying features in a photorealistic manner. We refer to this process as \u27likeness generation\u27.
Hogan, Bernie, McBride, Keegan, Bariach, Ben   +2 more
core   +1 more source

Word-likeness ratings of English-like non-words by Arabic and Chinese learners of English: implications for assessing proficiency

Frontiers in Language Sciences
The present study investigated English learners' subjective word-likeness ratings of English-like non-words. For both native Arabic and Mandarin speakers learning English, the subjective word-likeness ratings correlated with objective phonotactic ...
Faisal M. Aljasser, Yusen Wang, Michael S. Vitevitch   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Visual Metaphor: Likeness of Unlike Things in Cartoons

RUDN Journal of Studies in Literature and Journalism
The concept of metaphor is presented and analyzed in relation to the phenomenon of political cartoons. Guided by Conceptual Metaphor Theory, developed by Lakoff and Johnson as the theoretical framework, this study aims to examine how metaphors in ...
Mohsen Zarifian
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Like father, like son

eLife, 2017
Exposing male mice to nicotine or cocaine enables their male offspring to cope with high doses of either, which suggests that such paternal effects are generic, rather than being a response to a specific type of stress.
openaire   +3 more sources