Results 51 to 60 of about 49,716 (300)
Fundamental physical and chemical concepts behind "drug-likeness" and "natural product-likeness"
, 2019 The discovery of a drug is known to be quite cumbersome, both in terms of the microscopic fundamental research behind it and the industrial scale manufacturing process.
Ntie-Kang F. +3 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba +29 more
wiley +1 more source
Realism of the face lies in skin and eyes: Evidence from virtual and human agents
Computers in Human Behavior Reports, 2021 Despite advancements in computer graphics and artificial intelligence, it remains unclear which aspects of intelligent virtual agents (IVAs) make them identifiable as human-like agents.
Julija Vaitonytė +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques +5 more
wiley +1 more source
Blood, 2012 ![Figure][1] The peripheral smear of a 35-year-old man showed 47% bilobed neutrophils (panel A) and 45% band forms (panel B). A diagnosis of Pelger-Huet anomaly was considered. When a similar smear, seen earlier in a 3-year-old boy was remembered, it was learned that the patients were ...
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Unique Christian Therapeutic Counseling: Maximizing Results and Shortening Time
Bisma The Journal of Counseling, 2022 This article describes Christian therapeutic counseling that can help make the counseling process effective. The purpose of Christian therapeutic counseling is not only to want someone to experience recovery from the problem, but above all, the result ...
Royal Evendi Purba, Junifrius Gultom
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Profiling the natural product-likeness of Latin American compound libraries [PDF]
Compound databases of natural products play a crucial role in drug discovery and development projects and have implications in other areas, such as food chemical research, ecology and metabolomics. Recently, we put together the first version of the Latin
Ann-Kathrin, Prinz +35 more
core +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source