A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. [PDF]
In the present study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared to cisplatinum (CDDP) on a patient-derived orthotopic xenogrraft (PDOX) of a lung-metastasis from an osteosarcoma of a patient who failed CDDP therapy ...
Dry, Sarah M +15 more
core +1 more source
The treatment of primary tumors of the femur with chemotherapy (if indicated), resection and reconstruction with an endoprosthesis [PDF]
The treatment protocol of 15 patients with a primary tumor of the femur, including osteosarcoma, malignant fibrous histiocytoma and chondrosar-coma is presented. All patients had been selected for resection and reconstruction with an endoprosthesis.
Göeken, L.N.H. +10 more
core +7 more sources
Missing limb ischemia in dark-skinned patients: The badinjal sign
Limb ischemia is acute, chronic, or acute on chronic, and the prevalence of the latter is rising with the presence of an increasing aging population. When occlusion to the flow of blood is sudden, it results in acute limb ischemia, the early diagnosis of
Edwin Stephen +4 more
doaj +1 more source
Functional and psychological outcomes of delayed lower limb amputation following failed lower limb reconstruction [PDF]
The purpose of this study was to evaluate the functional and psychological outcomes of patients who underwent delayed lower limb amputation following failed limb salvage surgery.This retrospective, descriptive study evaluated functional outcomes using ...
Birkholtz, Franz +3 more
core +1 more source
Among the vascular injuries, the brachial artery injury is common one. This is a retrospective study of 90 patients admitted at Al-Sader teaching hospital in Najaf from the 1st of January 2007 to the 1st of January 2008.
WADHAH MAHBOBA +3 more
doaj +1 more source
Pathologic fracture does not influence prognosis in stage IIB osteosarcoma: a case–control study [PDF]
OBJECTIVE: This study tested the implication of pathologic fractures on the prognosis in stage IIb osteosarcoma. METHODS: A single center retrospective evaluation of clinical management and oncologic outcome was conducted with 15 pathological fracture ...
Dongqing Zuo +4 more
core +1 more source
Three-dimensional virtual bone bank system workflow for structural bone allograft selection: a technical report [PDF]
Structural bone allograft has been used in bone defect reconstruction during the last fifty years with acceptable results. However, allograft selection methods were based on 2-dimensional templates using X-rays.Thanks to preoperative planning platforms ...
Aponte Tinao, Luis +5 more
core +3 more sources
Limb salvage by femoral profundaplasty [PDF]
Summary One hundred and seven profundaplasties have been performed for rest pain or gangrene due to advanced arterial degeneration below the inguinal ligament. Local anaesthesia was used for 78 operations. There were 19 early failures (2 deaths and 17 amputations) and 16 later amputations. During 4·5 years of follow-up, 25 other patients
openaire +2 more sources
Spinal cord stimulation trial can control pain caused by chronic limb-threatening ischemia
Background: Patients with chronic limb-threatening ischemia experience long-duration pain during ulcer treatment. Hence, painkillers are gradually increased, but adverse events often occur.
Yuta Terabe
doaj +1 more source
Postoperative monitoring of lower limb free flaps with the CookâSwartz implantable doppler probe: A clinical trial [PDF]
Background: Free flaps to the lower limb have inherently high venous pressures, potentially impairing flap viability, which may lead to limb amputation if flap failure ensues. Adequate monitoring of flap perfusion is thus essential, with timely detection
Bannasch +28 more
core +1 more source

