Results 51 to 60 of about 536,726 (217)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Complex dynamics in biological systems arising from multiple limit cycle bifurcation
Journal of Biological Dynamics, 2016 In this paper, we study complex dynamical behaviour in biological systems due to multiple limit cycles bifurcation. We use simple epidemic and predator–prey models to show exact routes to new types of bistability, that is, bistability between equilibrium
P. Yu, W. Lin
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
A Simple Predator-Prey Population Model with Rich Dynamics
Applied Sciences, 2016 A non-smooth switched harvest on predators is introduced into a simple predator-prey model with logistical growth of the prey and a bilinear functional response.
Bing Li +3 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Three crossing limit cycles in planar piecewise linear systems with saddle-focus type
Electronic Journal of Qualitative Theory of Differential Equations, 2015 This paper presents an analysis on the appearance of limit cycles in planar Filippov system with two linear subsystems separated by a straight line. Under the restriction that the orbits with points in the sliding and escaping regions are not considered,
Liping Li
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
On the uniqueness of limit cycles in discontinuous Liénard-type systems
Electronic Journal of Qualitative Theory of Differential Equations, 2015 In this paper, we investigate the uniqueness and stability of limit cycles for a nonlinear Liénard-type differential system with a discontinuity line. By employing a transformation technique and considering the characteristic exponent of periodic orbit ...
Fangfang Jiang, Jitao Sun
doaj +1 more source
Synchronization of spin-driven limit cycle oscillators optically levitated in vacuum. [PDF]
Nat Commun, 2023 Brzobohatý O +7 more
europepmc +1 more source