Results 81 to 90 of about 3,704,002 (295)
Explicit limit cycles of a family of polynomial differential systems
Electronic Journal of Differential Equations, 2017 We consider the family of polynomial differential systems $$\displaylines{ x' = x+( \alpha y-\beta x) (ax^2-bxy+ay^2) ^{n}, \cr y' = y-( \beta y+\alpha x) (ax^2-bxy+ay^2) ^{n}, }$$ where a, b, $\alpha $, $\beta $ are real constants and n is ...
Rachid Boukoucha
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
ISOCHRONOUS FAMILIES OF LIMIT CYCLES
Electronic Journal of Differential Equations, 2018 In the work, the authors study dynamical systems with oscillations, and in particular they consider the frequency of such oscillations. An important problem is to know when the frequency of some oscillation does not depend on a parameter of the system.
Romina Cobiaga, Walter Reartes
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A frequency-domain approach to the analysis of stability and bifurcations in nonlinear systems described by differential-algebraic equations [PDF]
, 2007 A general numerical technique is proposed for the assessment of the stability of periodic solutions and the determination of bifurcations for limit cycles in autonomous nonlinear systems represented by ordinary differential equations in the differential ...
Bonani, Fabrizio +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Complex dynamics in biological systems arising from multiple limit cycle bifurcation
Journal of Biological Dynamics, 2016 In this paper, we study complex dynamical behaviour in biological systems due to multiple limit cycles bifurcation. We use simple epidemic and predator–prey models to show exact routes to new types of bistability, that is, bistability between equilibrium
P. Yu, W. Lin
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source