Results 51 to 60 of about 5,522,817 (294)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Bifurcation Analysis of a Stochastically Driven Limit Cycle [PDF]
, 2018 We establish the existence of a bifurcation from an attractive random equilibrium to shear-induced chaos for a stochastically driven limit cycle, indicated by a change of sign of the first Lyapunov exponent.
Engel, Maximilian +2 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On equilibration and coarsening in the quantum O(N) model at infinite $N$
, 2013 The quantum O(N) model in the infinite $N$ limit is a paradigm for symmetry-breaking. Qualitatively, its phase diagram is an excellent guide to the equilibrium physics for more realistic values of $N$ in varying spatial dimensions ($d>1$).
Chandran, Anushya +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Non-equilibrium Statistical Mechanics of Two-dimensional Vortices [PDF]
, 2018 It has been observed empirically that two dimensional vortices tend to cluster forming a giant vortex. To account for this observation Onsager introduced a concept of negative absolute temperature in equilibrium statistical mechanics.
Levin, Yan, Pakter, Renato
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Analysis of Slope Stability Using Limit Equilibrium
Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2010 In achievement of slope load sustainability using mixed soil technique, is considered acceptable the method for slope construction technology. This paper deals with evaluation of mixed soil technique for construction of stable slope and proves the soil ...
Abdoullah Namdar
doaj
Frontiers in Earth Science, 2022 The critical acceleration model plays an important role in seismic slope stability and determines the predictive accuracy of regional seismic landslide hazard assessments.
Cheng Li +4 more
doaj +1 more source