Results 61 to 70 of about 209,133 (315)

Recent advances in stability analysis and design of 3D slopes

Frontiers in Built Environment
Slope failures in nature and engineering are typically three-dimensional (3D). The rotational failure mechanism derived from the variational limit equilibrium (LE) method shows superior performance in the stability analysis of the 3D slope.
Fei Zhang, Shilin Jia, Yufeng Gao
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Equilibrium Propagation Without Limits

CoRR
We liberate Equilibrium Propagation (EP) from the limit of infinitesimal perturbations by establishing a finite-nudge foundation for local credit assignment. By modeling network states as Gibbs-Boltzmann distributions rather than deterministic points, we prove that the gradient of the difference in Helmholtz free energy between a nudged and free phase ...
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Reclassification of thermal equilibrium phase-transitions in thermodynamic limit systems

Scientific Reports
For relaxor-ferroelectrics and relaxor-ferromagnets, the initial Ehrenfest-classification gives no phase-transition that contradicts the measured order-parameter, while the classification according to order-parameter and its derivatives raises the ...
Lai Wei, Li-Li Zhang, Yi-Neng Huang
doaj   +1 more source

Numerical Optimization Analyses of Dangerous Rock Mass Sliding Failure Under Freeze-thaw Cycles

工程科学与技术, 2023
The action of freeze-thaw (F–T) cycles is the main inducement for the collapse and instability of dangerous rock mass in cold regions, and it is particularly important to carry out numerical optimization analysis on the disaster pregnant factors of ...
Jiajun SHU, Zhengding DENG, Jingzhu HUANG, Bingni WU, Xingqiu ZHANG   +4 more
doaj  

Influence of impact forces on the strength characteristics of the railway roadbed

Вестник Научно-исследовательского института железнодорожного транспорта, 2017
The article presents the results of studies on the influence of impact forces on the strength characteristics of the soil of the main site of the roadbed (MSRB). It is shown that impulsive shock forces of 360 ...
O. G. Krasnov, N. N. Astanin
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source