Results 31 to 40 of about 13,451,313 (256)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prospects for the use of inulin and its modifications in the food, cosmetic and pharmaceutical industries

Vestnik MGTU
The paper contains a review of modern data on the use of the polysaccharide inulin and its modifications in various industries. Data on the use of native inulin in various food technologies have been presented.
Skorodumov A. S., Nesterov E. D., Gorn D. S., Barkanov A. V., Shanenko E. F.   +4 more
doaj   +1 more source

Mass thickness detection and verification for radiation processing products based on X-ray detection technology

Fushe yanjiu yu fushe gongyi xuebao, 2021
To quickly obtain the mass thickness and predetermine dose distribution of electron beam irradiated products, a new detection method was developed based on X-ray detection technology.
LIU Yanqin, QIN Huaili, LIANG Aifeng, KUANG Shan, YANG Guang, WANG Qiang, LIU Jingjing   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Combining fruquintinib with TAS-102 as a promising strategy: antitumor activity in preclinical colorectal and gastric cancer xenograft models

BMC Cancer
Background The combination of bevacizumab and TAS-102 has emerged as a treatment option for metastatic colorectal cancer (CRC). Bevacizumab is an anti-VEGF-A antibody, and TAS-102 is a cytotoxic nucleotide analog.
Takahito Hara, Megumi Morimoto, Masaaki Kakehi, Momoko Kamedani, Miyu Nakayama, Syunsuke Yamamoto, Tsuyoshi Osaka, Junpei Soeda, Hideaki Bando, Takayuki Yoshino   +9 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Silverhawk vessel chartered by Colonial Sugar Refining Limited

, 2022
Deposit Z638 consists of photographic proofs arranged in 75 albums illustrating all types of company activities, personnel, social and sporting events, refineries and factories, Mount Newman opening, bulk sugar terminals, aerial views of mills and ...
Photographer: Jim Hobden, Colonial Sugar Refining Company Limited (1855 -)   +1 more
core   +2 more sources

Application Function Design for UPFC Online Operation Optimization Decision-making

Zhongguo dianli, 2021
Due to the lack of guide tools for UPFC real-time operation optimization, the powerful power flow control capability of UPFC cannot be played flexibly.
Feng LI, Huimin PENG, Huling YUAN, Fangru WAN, Tiangang HUANG, Wei LI   +5 more
doaj   +1 more source

The Blinds Shop Company Limited Brand Identity Project [PDF]

, 2008
The Blinds Shop offers made to measure window blinds catering to all markets across Ireland. The Blinds Shop required a clean, bold and modern logo using fresh colours and imagery.
Dee, Peter
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source