Results 11 to 20 of about 1,298 (167)

Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics [PDF]

Molecules, 2019
Limonin is a natural tetracyclic triterpenoid compound, which widely exists in Euodia rutaecarpa (Juss.) Benth., Phellodendron chinense Schneid., and Coptis chinensis Franch.
Shunming Fan, Chunling Zhang, Ting Luo, Jiaqi Wang, Yu Tang, Zhimin Chen, Lingying Yu   +6 more
doaj   +5 more sources

Limonin induces ferroptosis in cervical squamous cell carcinoma by activating the expression of soluble epoxide hydrolase 2 protein. [PDF]

PLoS ONE
Natural products are a rich sources for developing anti-cancer drugs with low toxicity and high efficiency. Limonin has anti-cancer activity; however, its effect on cervical squamous cell carcinoma remains unreported. The aim of this study was to explore
Qi Wu, Suning Bai, Pei Wang, Lina Han, Liyun Song, Luyang Su, Yanan Ren   +6 more
doaj   +2 more sources

Limonin alleviates pyroptosis and inflammatory responses in cardiomyocytes of myocardial ischemia-reperfusion mice by inhibiting the caspase-3/GSDME pathway [PDF]

Frontiers in Immunology
PurposeMyocardial ischemia-reperfusion (I/R) is characterized by myocardial cell death and exacerbated inflammatory responses that seriously affect cardiac function and patient prognosis. Limonin is a natural compound extracted from citrus fruits and has
Jianlong Li, Jianlong Li, Zhe Li, Pengran Wang, Zhian Jiang   +4 more
doaj   +2 more sources

Limonin attenuates hyperlipidemia by regulating the gut microbiota-bile acid-farnesoid X receptor axis [PDF]

Journal of Translational Medicine
Background Hyperlipidemia is an established risk factor for cardiovascular disease. Limonin, a natural tetracyclic triterpenoid compound found in the traditional Chinese herb Tangerine peel and citrus fruits, has been shown to ameliorate hyperlipidemia ...
Linzi Li, Wen Sun, Ting Tan, Jinlian Xu, Ying Chen, Yumiao Chen, Guang Gao, Xu Ai, Jing Zhou, Yaoyao Li, Daoping Zhang, Shanshan Lei   +11 more
doaj   +2 more sources

Compromised blood-brain barrier in traumatic brain injury model of Danio rerio: A unique window to demonstrate restoration of behavioral, cellular, and neurochemical deficits by limonin [PDF]

Iranian Journal of Basic Medical Sciences
Background: Traumatic Brain Injury (TBI) poses a significant risk factor for various neurological complications, ranging from acute manifestations in severe cases to insidious onset in mild instances, often leading to fatal outcomes with elusive ...
Juwala Malinika, Lalitha Vaidyanathan, Madhan kumar Srinivasan, Sangeetha Chellapandi   +3 more
doaj   +2 more sources

Dual Ligand-Enabled Nondirected C─H Olefination of (Hetero)Arenes for the Synthesis of Clickable Derivatives. [PDF]

Chemistry
We report an efficient method for late‐stage installation of “clickable” alkyne groups into diverse (hetero)arenes. Using a dual‐ligand palladium catalyst that combines an NASA ligand with an N‐heterocycle, an acrylate unit bearing a terminal alkyne can be introduced via nondirected C─H activation.
Braga T, Hergert M, van Gemmeren M.
europepmc   +2 more sources

Limonin Exhibits Anti-Inflammatory Effects by Inhibiting mTORC1 and Mitochondrial Reactive Oxygen Species in Psoriatic-like Skin Inflammation [PDF]

Antioxidants
Psoriasis is a chronic inflammatory skin disorder characterized by abnormal immune responses and keratinocyte hyperproliferation. Limonin, a bioactive compound found in citrus fruits, has anti-inflammatory properties in various models; however, its ...
Seung Taek Lee, Jong Yeong Lee, Ha Eun Kim, Jun-Young Park, Jin Kyeong Choi   +4 more
doaj   +2 more sources

In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2 [PDF]

Scientific Reports
Emerging and re-emerging respiratory viruses represent a continuing threat to human health. The pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza A viruses (IAVs) are co-circulating, presenting serious threats to public ...
Gomaa Mostafa-Hedeab, Akram Hegazy, Islam Mostafa, Ibrahim H. Eissa, Ahmed M. Metwaly, Hany Abdelfattah Elhady, Abozer Y. Eledrdery, Sager Holyl Alruwaili, Alaa Oqalaa E. Alibrahim, Fawaz O. Alenazy, Muhannad Faleh Alanazi Alruwaili, Thamer Alshami Marghel, Muharib Alruwaili, Alaaeldin Mohamed Saad, Mahmoud Bayoumi, Assem Mohamed El-Shazly, Luis Martinez-Sobrido, Ahmed Mostafa   +17 more
doaj   +2 more sources

Biochemical mechanisms underlying the differences in fruit characteristics among three kumquat varieties [PDF]

Frontiers in Plant Science
To elucidate different fruit trait mechanisms among Changshou (FOT) (Fortunella obovata Tanaka), Liuyang (FCSLY) (Fortunella crassifolia Swingle), and Huapi (FCSHP) (Fortunella crassifolia Swingle) kumquats, fruit traits, and their metabolite ...
Manti Li, Manti Li, Zili Yi, Zili Yi, Haole Shang, Haole Shang, Changwei Zhu, Changwei Zhu, Hongmei Huang, Hongmei Huang   +9 more
doaj   +2 more sources

Aporocactus flagelliformis water extract and limonin suppresses P2Y purinoceptor 14-mediated proinflammatory features in 3D4/31 porcine alveolar macrophages [PDF]

Journal of Animal Science and Technology
Respiratory diseases have been recognized as a significant cause of reduced livestock productivity since 1995. Respiratory diseases in the swine industry caused by both biological and non-biological factors are collectively referred to as porcine ...
Hyungkuen Kim, Hyun Sik Jun, Ki-Duk Song, Sung-Jo Kim   +3 more
doaj   +2 more sources