Results 21 to 30 of about 7,068 (252)

A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells

International Journal of Molecular Sciences, 2022
The seed oil of Carapa guianensis Aublet (Andiroba) has been used in folk medicine for its insect-repelling, anti-inflammatory, and anti-malarial activities. This study aimed to examine the triglyceride (TG) reducing effects of C.
Akifumi Nagatomo, K. Ninomiya, Shinsuke Marumoto, Chie Sakai, Shuta Watanabe, Wakana Ishikawa, Yoshiaki Manse, Takashi Kikuchi, Takeshi Yamada, R. Tanaka, O. Muraoka, T. Morikawa   +11 more
semanticscholar   +1 more source

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.

Cell Chemical Biology, 2021
Three limonoid natural products with selective anti-proliferative activity against BRAF(V600E) and NRAS(Q61K)-mutation-dependent melanoma cell lines were identified.
Hyelim Cho, Qiong Shen, Lydia H Zhang, M. Okumura, A. Kawakami, J. Ambrose, Frederic D. Sigoillot, H. Miller, S. Gleim, Amanda Cobos-Correa, Ying Wang, P. Piéchon, G. Roma, F. Eggimann, Charles Moore, Peter Aspesi, F. Mapa, H. Burks, Nathan T. Ross, P. Krastel, M. Hild, T. Maimone, D. Fisher, Daniel K. Nomura, John A. Tallarico, Stephen M. Canham, J. Jenkins, W. Forrester   +27 more
semanticscholar   +1 more source

A new havanensin-type limonoid from Chisocheton macrophyllus

Applied Biological Chemistry, 2021
A new havanensin-type limonoid, 16β-hydroxydysobinin ( 1 ), along with four known limonoids ( 2–5 ), have been isolated from the seeds of Chisocheton macrophyllus .
Nurlelasari, Intan Rahmayanti, S. Salam, A. Safari, D. Harneti, R. Maharani, A. Hidayat, M. Tanjung, R. Retnowati, Y. Shiono, U. Supratman   +10 more
semanticscholar   +1 more source

New cytotoxic obacunone-type limonoid and others constituents from the stem bark of Carapa procera DC (Meliaceae)

Natural Product Research, 2021
The phytochemical study of the CH2Cl2- MeOH (1:1, v/v) extract of the stem bark of Carapa procera DC (Meliaceae) led to the isolation and characterisation of a new natural limonoid 7β-obacunol (6), along with seven known compounds.
Raduis Melong, Pierre Carolle Tamokoue Kengne, J. Dzoyem, Angelbert Awantu Fusi, E. Allémann, F. Delie, C. Bochet, U. Beifuss, G. W. Kapche   +8 more
semanticscholar   +1 more source

Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro

Journal of chemistry, 2021
The plants of Meliaceae are native to tropical and subtropical regions as the Americas, west India, Southeast Asia, and Southern China. Many species of the genera Khaya, Swietenia, Aphanamixis, and Melia in this family are known as medicinal plants and ...
Thanh Nguyen Tan, Hieu Tran Trung, Quang Le Dang, Hien Vu Thi, H. Vu, Tuan Nguyen Ngoc, Hoa Thi Do, T. Nguyen, D. N. Quang, Thang Tran Dinh   +9 more
semanticscholar   +1 more source

Tracing the biosynthetic origin of limonoids and their functional groups through stable isotope labeling and inhibition in neem tree (Azadirachta indica) cell suspension

BMC Plant Biology, 2018
Background Neem tree serves as a cornucopia for triterpenoids called limonoids that are of profound interest to humans due to their diverse biological activities.
Thiagarayaselvam Aarthy, Fayaj A. Mulani, Avinash Pandreka, Ashish Kumar, Sharvani S. Nandikol, Saikat Haldar, Hirekodathakallu V. Thulasiram   +6 more
doaj   +1 more source

The chemistry and pharmacology of citrus limonoids [PDF]

, 2016
Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins.
Ahmad, Bernays, Bilal, Bilal, Chan, Choodej, Codoner-Franch, Fang, Gai, Garnier-Suillerot, Giovanni Lentini, Habtemariam, Habtemariam, Habtemariam, Hasegawa, Hasegawa, Herman, Ikegami, Jayaprakasha, Jeong, Juan-Badaturugea, Kondo, Maria Cavalluzzi, McIntosh, Murthy, Nikkon, Patil, Patil, Pichaiyongvongdee, Poulose, Poulose, Ram, Roberta Gualdani, Rodríguez, Sato, Solomon Habtemariam, Todaro, Xu   +37 more
core   +3 more sources

Trichilones A–E: New Limonoids from Trichilia adolfi

Molecules, 2021
In addition to the trichilianones A–D recently reported from Trichilia adolfi, a continuing investigation of the chemical constituents of the ethanol extract of the bark of this medicinal plant yielded the five new limonoids 1–5.
Mariela Gonzalez-Ramirez, Ivan Limachi, Sophie Manner, Juan C. Ticona, Efrain Salamanca, Alberto Gimenez, Olov Sterner   +6 more
doaj   +1 more source

HIRTINOL A: A NEW LIMONOID FROM THE SEEDS OF Trichilia hirta Linneaus (Meliaceae) [PDF]

Química Nova
Species of the genus Trichilia (Meliaceae) produce a significant variety of secondary metabolites. Limonoids, the largest part of these compounds, have attracted considerable attention from the scientific community, due to their structural diversity and ...
Renata Rodrigues da Silva Robaina, Gabriela Dinis, Lucas Silva Abreu, Raimundo Braz-Filho, Ivo José Curcino Vieira   +4 more
doaj   +1 more source

New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity

Molecules, 2016
Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1–5, named chukbularisins A–E, were elucidated by spectroscopic techniques (IR ...
Jun-Lin Peng, Jun Wang, Fan-Dong Kong, Zi-Qi Liu, Pei Wang, Cui-Juan Gai, Bei Jiang, Wen-Li Mei, Hao-Fu Dai   +8 more
doaj   +1 more source