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Assessment of the in vitro anti-diabetic activity with molecular dynamic simulations of limonoids isolated from Adalia lemon peels [PDF]

Scientific Reports
Limonoids are important constituents of citrus that have a significant impact on promoting human health. Therefore, the primary focus of this research was to assess the overall limonoid content and isolate limonoids from Adalia lemon (Citrus limon L ...
Amal M. El-Feky, Wael Mahmoud Aboulthana, Ahmed A. El-Rashedy   +2 more
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Limonoids From the Genus Melia (Meliaceae): Phytochemistry, Synthesis, Bioactivities, Pharmacokinetics, and Toxicology

Frontiers in Pharmacology, 2022
Limonoids, as the vital bioactive chemical compounds in genus Melia plants, have attracted significant attention owing to their exclusive structural characteristics and remarkable biological activity.
Wenxiang Fan, Linhong Fan, Zhengtao Wang, Li Yang, Li Yang   +4 more
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Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Antioxidants, 2022
The increased consumption of fruits, vegetables, and whole grains contributes to the reduced risk of many diseases related to metabolic syndrome, including neurodegenerative diseases, cardiovascular disease (CVD), diabetes, and cancer.
Ramesh Kumar Saini, Arina Ranjit, Kavita Sharma, Parchuri Prasad, Xiaomin Shang, Karekal Girinur Mallikarjuna Gowda, Young-Soo Keum   +6 more
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Inhibitory activity of limonoids from Khaya grandifoliola C.DC (Meliaceae) against hepatitis C virus infection in vitro [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: A fraction from Khaya grandifoliola has recently been shown to inhibit hepatitis C virus (HCV) infection and three limonoids (17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and 7-deacetoxy-7R-hydroxygedunin) were purified from ...
Kouam Arnaud, Njayou Frédéric Nico, Yuan Fei, Babayemi Oladejo, He Hongtao, Mkounga Pierre, Moundipa Paul   +6 more
doaj   +2 more sources

Biological activities of limonoids in the Genus Khaya (Meliaceae): a review

Future Journal of Pharmaceutical Sciences, 2021
Background Limonoids are a class of highly oxygenated modified triterpenoids with a diverse range of biological activities. Although with restricted occurrence in the plant kingdom, these compounds are found extensively in the Meliaceae and Rutaceae ...
Tomi Lois Olatunji, Christiana Adeyinka Odebunmi, Ademola Emmanuel Adetunji   +2 more
doaj   +2 more sources

Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking [PDF]

Molecules, 2023
Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem is highly prized for its exceptional quality, while its leaves are valued for their high content of phragmalin-type limonoids, a subclass of compounds ...
José Diogo E. Reis, Paulo Wender P. Gomes, Paulo R. da C. Sá, Sônia das G. S. R. Pamplona, Consuelo Yumiko Y. e Silva, Maria Fátima das G. F. da Silva, Anupam Bishayee, Milton Nascimento da Silva   +7 more
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Effect of Yuzu (Citrus junos) Seed Limonoids and Spermine on Intestinal Microbiota and Hypothalamic Tissue in the Sandhoff Disease Mouse Model

Medical Sciences, 2021
The effect of limonoids and spermine (Spm) extracted from yuzu (Citrus junos) seeds on the gut and the brain in a mouse model with Sandhoff disease (SD) was investigated. Wild-type and SD mice were fed a normal diet, or a diet supplemented with limonoid,
Mayumi Minamisawa, Takuma Suzumura, Sudeep Bose, Tetsuyuki Taniai, Gota Kawai, Kyoko Suzuki, Akira Yamaguchi, Shoji Yamanaka   +7 more
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An Overview of Limonoids and Other Natural Products Isolated from the Medicinal Plant Cipadessa baccifera and Its Pharmacological Properties [PDF]

Plants
The Asian medicinal plant Cipadessa baccifera (Roth) Miq., also known as C. fruticosa or C. cinerascens (Ranabili or Nalbila), has long been used in Ayurvedic medicine to treat dysentery, skin disorders, rheumatism and parasitic infections.
Christian Bailly
doaj   +2 more sources

Transcriptome and metabolome profiling of the medicinal plant Dictamnus dasycarpus reveal key genes involved in quinoline alkaloids biosynthesis and limonoids biosynthesis [PDF]

BMC Plant Biology
Background As a member of Rutaceae family, Dictamnus dasycarpus Turcz. represents a prominent medicinal plant and economically valuable crop in traditional Chinese medicine, and is renowned for its therapeutic efficacy in treating dermatological ...
Jiawei Mao, Jianhan Liu, Yuying Hou, Xue Fang, Xueqi Cheng, Lei Tian, Yue Ma, Haibo Yin, Xiaoxia Chen   +8 more
doaj   +2 more sources

Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models

Antioxidants, 2021
The COVID-19 pandemic represents an unprecedented global emergency. Despite all efforts, COVID-19 remains a threat to public health, due to the complexity of mass vaccination programs, the lack of effective drugs, and the emergence of new variants.
Fabio Magurano, Marzia Sucameli, Pasquale Picone, Matteo Micucci, Melissa Baggieri, Antonella Marchi, Paola Bucci, Silvia Gioacchini, Giorgia Catinella, Gigliola Borgonovo, Sabrina Dallavalle, Domenico Nuzzo, Andrea Pinto   +12 more
doaj   +2 more sources