Results 21 to 30 of about 14,293 (184)

Evaluation of the Effects of Interfering Factors on the Bacterial Endotoxin Testing of Radiopharmaceuticals

open access: yesKorean Journal of Clinical Laboratory Science
The endotoxin test is based on the reaction between Limulus Amebocyte Lysate (LAL) and the lipopolysaccharides of Gram-negative bacteria. In this study, we sought to identify factors that interfere with the LAL testing of radiopharmaceuticals and ...
Jun Young PARK
doaj   +1 more source

The Limulus test in experimental and clinical endotoxaemia

open access: yesJournal of British Surgery, 1974
Abstract Gram-negative septicaemia is being recognized (is an increasingly common cause of mortality in hospital practice. In this paper the value of a simple and rapid test which can be used to detect the presence of circulating endotoxins is assessed in experimental and clinical situations.
D P, Fossard, V V, Kakkar
openaire   +2 more sources

Endotoxins Affecting Human Health during Agricultural Practices: An Overview

open access: yesAppliedChem, 2022
Agricultural operations and the processing sector generate dust laden with endotoxin in the workplace. Endotoxin, a pro-inflammatory agent, has adverse effects on health, especially in the lungs, as exposure to endotoxin reduces lung function capacity ...
B. Surya Kumar Chhetry   +3 more
doaj   +1 more source

Validation of moist and dry heat processes used for sterilization and depyrogenation during ampoules manufacturing [PDF]

open access: yesJournal of Advanced Biomedical and Pharmaceutical Sciences, 2020
Pyrogens are fever-producing substances, which are metabolic products of microorganisms and most potent pyrogens are the endotoxins. Depyrogenation can be defined as the elimination of all pyrogenic substances which is an important part of the ...
Ahmed Rashed   +3 more
doaj   +1 more source

An expert review on current approaches for endotoxin detection in various biological products

open access: yesArchives of Pharmaceutical Sciences Ain Shams University, 2019
Endotoxin is heat-stable lip polysaccharide (LPS) present in the outer membrane of the cell wall of Gram-negative bacteria. All parenteral preparations, as well as tissue implants, must be with no pyrogenic level of endotoxin or other related materials ...
Mohammed A. Elkhateeb   +2 more
doaj   +1 more source

Improvement of the Micromethod for the Limulus Lysate Test [PDF]

open access: yesMicrobiology and Immunology, 1978
AbstractFrauch's micro‐slide method was improved to facilitate the endpoint‐determination of the Limulus test. Two precise observations, by inverted phase contrast microscopy and with a staining procedure, were newly performed as additions to the slide test.
openaire   +2 more sources

A Novel Diagnostic Method for Invasive Fungal Disease Using the Factor G Alpha Subunit From Limulus polyphemus

open access: yesFrontiers in Microbiology, 2021
Deaths due to invasive fungal disease (IFD) have been increasing every year. Early and rapid detection is important to reduce the mortality rate associated with IFD.
Fang Cui   +3 more
doaj   +1 more source

Analysis of commercially available snake antivenoms reveals high contents of endotoxins in some products

open access: yesToxicon: X
As injectable therapeutics, snake antivenoms must meet specifications for endotoxin content. The Limulus amebocyte lysate (LAL) test was used to evaluate the endotoxin content in several commercially available antivenoms released for clinical use. It was
Gabriela Solano   +7 more
doaj   +1 more source

Measurement of endotoxins with the limulus test in burned patients [PDF]

open access: yesJournal of Hygiene, 1979
SUMMARYHigh titres of endotoxin as measured by the Limulus test were usually found in burned patients who had raised body temperatures, and were colonized with gram-negative bacteria; also some infected patients showed raised endotoxin without a raised temperature.Patients vaccinated with an antipseudomonas vaccine rarely showed endotoxin in their ...
R J, Jones, E A, Roe
openaire   +2 more sources

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

open access: yesAllergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert   +9 more
wiley   +1 more source

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