Results 91 to 100 of about 4,813,932 (329)

The MOV10 Helicase Inhibits LINE-1 Mobility [PDF]

Journal of Biological Chemistry, 2013
LINE-1 (long interspersed element 1) is an autonomous non-long terminal repeat retrotransposon. Its replication often causes mutation and rearrangement of host genomic DNA. Accordingly, host cells have evolved mechanisms to control LINE-1 mobility. Here, we report that a helicase named MOV10 effectively suppresses LINE-1 transposition.
Xiaoyu, Li, Jianyong, Zhang, Rui, Jia, Vicky, Cheng, Xin, Xu, Wentao, Qiao, Fei, Guo, Chen, Liang, Shan, Cen   +8 more
openaire   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation [PDF]

, 2011
Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined.Objectives We aimed at identifying short- and long-term ...
Apostoli, Pietro, Baccarelli, Andrea, Bertazzi, Pier Alberto, Bollati, Valentina, Bonzini, Matteo, Cantone, Laura, Hou, Lifang, Marinelli, Barbara, Pegoraro, Valeria, Rizzo, Giovanna, Schwartz, Joel David, Tarantini, Letizia   +11 more
core   +1 more source

Mixing state of oxalic acid containing particles in the rural area of Pearl River Delta, China: implications for the formation mechanism of oxalic acid [PDF]

Atmospheric Chemistry and Physics, 2017
The formation of oxalic acid and its mixing state in atmospheric particulate matter (PM) were studied using a single-particle aerosol mass spectrometer (SPAMS) in the summer and winter of 2014 in Heshan, a supersite in the rural area of the Pearl ...
C. Cheng, C. Cheng, M. Li, M. Li, C. K. Chan, H. Tong, C. Chen, D. Chen, D. Wu, D. Wu, L. Li, L. Li, C. Wu, C. Wu, P. Cheng, P. Cheng, W. Gao, W. Gao, Z. Huang, Z. Huang, X. Li, X. Li, Z. Zhang, Z. Zhang, Z. Fu, Y. Bi, Z. Zhou, Z. Zhou   +27 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Analisis Kontingensi Sistem Tenaga Listrik Dengan Metode Bounding [PDF]

, 2012
The bounding method is one of the contingency analysis method for detecting branch flow violations. Three subnetworks in the bounding method namely N1, N2, and N3 will give information regarding those subnetworks that may not go overload and those that ...
Rahmawati, N. (Nurul), Syafii, S. (Syafii)   +1 more
core   +1 more source

Heavy Metals Stimulate Human LINE-1 Retrotransposition [PDF]

International Journal of Environmental Research and Public Health, 2005
L1 and Alu elements are among the most active retroposons (mobile elements) in the human genome. Several human diseases, including certain forms of breast cancer and leukemia, are associated with L1 and Alu insertions in functionally important areas of the genome.
Shubha P, Kale, Lakisha, Moore, Prescott L, Deininger, Astrid M, Roy-Engel   +3 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study [PDF]

, 2011
Background: Recent data suggest a link between blood leukocyte DNA methylation, and cancer risk. However, reports on DNA methylation from a prospective study are unavailable for gastric cancer.
Baccarelli, Andrea, Chow, W-H, Gao, Y, Gao, Y-T, Hou, L, Ji, B-T, Li, H-L, Rothman, N, Shu, X O, Tarantini, L, Yang, G, Yu, K, Zheng, W   +12 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source