Results 91 to 100 of about 4,881,979 (331)

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer [PDF]

LINE-1 retrotransposons are abundant repetitive elements of viral origin, which in normal cells are kept quiescent through epigenetic mechanisms.
Cruickshanks, H.A, Dunican, D.S., Lee, A., Lund, Jonathan N., Meehan, R.R., Sproul, D., Tufarelli, C., Vafadar-Isfahani, N.   +7 more
core   +1 more source

Prenatal Arsenic Exposure and DNA Methylation in Maternal and Umbilical Cord Blood Leukocytes [PDF]

, 2012
Background: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. Objectives: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes.
Baccarelli, Andrea, Christiani, David C., Hoffman, Elaine Borland, Hsueh, Yu-Mei, Kile, Molly Louise, Mahiuddin, Golam, Mostofa, Golam, Quamruzzaman, Quazi, Rahman, Mahmuder, Tarantini, Letizia, Wright, Robert O.   +10 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation [PDF]

, 2011
Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined.Objectives We aimed at identifying short- and long-term ...
Apostoli, Pietro, Baccarelli, Andrea, Bertazzi, Pier Alberto, Bollati, Valentina, Bonzini, Matteo, Cantone, Laura, Hou, Lifang, Marinelli, Barbara, Pegoraro, Valeria, Rizzo, Giovanna, Schwartz, Joel David, Tarantini, Letizia   +11 more
core   +1 more source

Word and bit line operation of a 1 × 1 μm2 superconducting vortex-based memory

Nature Communications, 2023
The lack of dense random access memory is one of the main bottlenecks for the creation of a digital superconducting computer. In this work we study experimentally vortex-based superconducting memory cells. Three main results are obtained.
Taras Golod, Lise Morlet-Decarnin, Vladimir M. Krasnov   +2 more
doaj   +1 more source

Heavy Metals Stimulate Human LINE-1 Retrotransposition [PDF]

International Journal of Environmental Research and Public Health, 2005
L1 and Alu elements are among the most active retroposons (mobile elements) in the human genome. Several human diseases, including certain forms of breast cancer and leukemia, are associated with L1 and Alu insertions in functionally important areas of the genome.
Shubha P, Kale, Lakisha, Moore, Prescott L, Deininger, Astrid M, Roy-Engel   +3 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study [PDF]

, 2011
Background: Recent data suggest a link between blood leukocyte DNA methylation, and cancer risk. However, reports on DNA methylation from a prospective study are unavailable for gastric cancer.
Baccarelli, Andrea, Chow, W-H, Gao, Y, Gao, Y-T, Hou, L, Ji, B-T, Li, H-L, Rothman, N, Shu, X O, Tarantini, L, Yang, G, Yu, K, Zheng, W   +12 more
core   +1 more source

Collaborative Control of Lane Changing for Autonomous Vehicles in High‐Density Heterogeneous Traffic Flow

IET Intelligent Transport Systems
To solve the problem of lane changing cooperative control of autonomous vehicles in high‐density heterogeneous traffic flow, by analyzing the characteristics of the mandatory lane changing behavior of autonomous vehicles, a dual‐lane utility calculation ...
Yan Liu, Jiaqi Ding
doaj   +1 more source

Correction to: De Novo Somatic Mosaicism of CYBB Caused by Intronic LINE‑1 Element Insertion Resulting in Chronic Granulomatous Disease [PDF]

, 2023
Lang Yu, Wenhui Li, Ge Lv, Gan Sun, Lu Yang, Junjie Chen, Lina Zhou, Yuan Ding, Zhiyong Zhang, Xuemei Tang, Yunfei An, Xiaodong Zhao   +11 more
openalex   +1 more source