Results 81 to 90 of about 28,196,398 (315)

An intronic LINE-1 regulates IFNAR1 expression in human immune cells

Mobile DNA, 2023
Background Despite their origins as selfish parasitic sequences, some transposons in the human genome have been co-opted to serve as regulatory elements, contributing to the evolution of transcriptional networks.
Carmen A. Buttler, Daniel Ramirez, Robin D. Dowell, Edward B. Chuong   +3 more
doaj   +1 more source

LINE-1 Elements in Structural Variation and Disease [PDF]

Annual Review of Genomics and Human Genetics, 2011
The completion of the human genome reference sequence ushered in a new era for the study and discovery of human transposable elements. It now is undeniable that transposable elements, historically dismissed as junk DNA, have had an instrumental role in sculpting the structure and function of our genomes.
Beck, CR, Garcia-Perez, JL, Badge, RM, Moran, JV   +3 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Collaborative Control of Lane Changing for Autonomous Vehicles in High‐Density Heterogeneous Traffic Flow

IET Intelligent Transport Systems
To solve the problem of lane changing cooperative control of autonomous vehicles in high‐density heterogeneous traffic flow, by analyzing the characteristics of the mandatory lane changing behavior of autonomous vehicles, a dual‐lane utility calculation ...
Yan Liu, Jiaqi Ding
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Multi-energy synergetic pathways for China’s new power system based on cost analysis [PDF]

Ziyuan Kexue
[Objective] China has vast development potential for wind and solar resources, but there is a spatial mismatch between resource endowments and load centers.
LI Ru, HU Yujie, ZHANG Chen
doaj   +1 more source

Observed deformation behavior of Gongbei Tunnel of Hong Kong-Zhuhai-Macao Bridge during construction

Yantu gongcheng xuebao, 2020
The excavation of shallow buried tunnels with super-large section in coastal water-rich strata with complex geological conditions faces a lot of risks. The surrounding soil is easy to be disturbed during excavation, causing the ground deformation.
ZHANG Dong-mei 1, 2, PANG Jian 2, REN Hui 3, HAN Lei 2
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source