Results 61 to 70 of about 4,929,883 (200)

Combination of Evolutionary Algorithms with Experimental Design, Traditional Optimization and Machine Learning [PDF]

, 2016
Evolutionary algorithms alone cannot solve optimization problems very efficiently since there are many random (not very rational) decisions in these algorithms.
Zhang, Qingfu
core  

LINE-1 (L1) Lineages in the Mouse [PDF]

Molecular Biology and Evolution, 2000
Recently, a rapidly amplifying family of mouse LINE-1 (L1) has been identified and named T(F). The evolutionary context surrounding the derivation of the T(F) family was examined through phylogenetic analysis of sequences in the 3' portion of the repeat.
S C, Hardies, L, Wang, L, Zhou, Y, Zhao, N C, Casavant, S, Huang   +5 more
openaire   +2 more sources

Retrotransposon-Encoded Reverse Transcriptase in the Genesis, Progression and Cellular Plasticity of Human Cancer [PDF]

, 2011
LINE-1 (Long Interspersed Nuclear Elements) and HERVs (Human Endogenous Retroviruses) are two families of autonomously replicating retrotransposons that together account for about 28% of the human genome.
Matteucci, C, Sinibaldi Vallebona, P, Spadafora, C   +2 more
core   +2 more sources

Genomic Deletions Created upon LINE-1 Retrotransposition [PDF]

Cell, 2002
LINE-1 (L1) retrotransposition continues to impact the human genome, yet little is known about how L1 integrates into DNA. Here, we developed a plasmid-based rescue system and have used it to recover 37 new L1 retrotransposition events from cultured human cells.
Gilbert, Nicolas, Lutz-Prigge, Sheila, Moran, John V.   +2 more
openaire   +2 more sources

Inhibition of LINE-1 Retrotransposition by Capsaicin [PDF]

International Journal of Molecular Sciences, 2018
Long interspersed nuclear element 1 (LINE-1 or L1) is a non-long terminal repeat (LTR) retrotransposon that constitutes approximately 17% of the human genome. Since approximately 100 copies are still competent for retrotransposition to other genomic loci, dysregulated retrotransposition of L1 is considered to be a major risk factor of endogenous ...
Nishikawa, Yuki, Nakayama, Ryota, Obika, Shunsuke, Ohsaki, Eriko, Ueda, Keiji, Honda, Tomoyuki   +5 more
openaire   +2 more sources

Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content: A Genetic Association Study [PDF]

, 2013
Background: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease.
Baccarelli, Andrea, Bollati, Valentina, Cassano, Patricia A, Clark, Andrew G., Gaziano, John Michael, Litonjua, Augusto Ampil, Schwartz, Joel David, Stover, Patrick J, Tucker, Katherine L, Weiss, Scott Tillman, Wells, Martin T, Wernimont, Susan M   +11 more
core   +1 more source

LINE-1 Retrotransposition Activity in Human Genomes [PDF]

Cell, 2010
Highly active (i.e., "hot") long interspersed element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome; however, the abundance of hot L1s in the human population remains largely unexplored. Here, we used a fosmid-based, paired-end DNA sequencing strategy to identify 68 full-length L1s that are ...
Beck, CR, Collier, P, Macfarlane, C, Malig, M, Kidd, JM, Eichler, EE, Badge, RM, Moran, JV   +7 more
openaire   +3 more sources

APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition [PDF]

Journal of Biological Chemistry, 2006
The human cytidine deaminase family APOBEC3 represents a novel group of proteins in the field of innate defense mechanisms that has been shown to be active against a variety of retroviruses. Here we examined whether members of the APO-BEC3 family have an impact on retrotransposition of human long interspersed nuclear elements (LINE-1s or L1s).
Heide, Muckenfuss, Matthias, Hamdorf, Ulrike, Held, Mario, Perković, Johannes, Löwer, Klaus, Cichutek, Egbert, Flory, Gerald G, Schumann, Carsten, Münk   +8 more
openaire   +2 more sources

Prenatal Arsenic Exposure and DNA Methylation in Maternal and Umbilical Cord Blood Leukocytes [PDF]

, 2012
Background: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. Objectives: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes.
Baccarelli, Andrea, Christiani, David C., Hoffman, Elaine Borland, Hsueh, Yu-Mei, Kile, Molly Louise, Mahiuddin, Golam, Mostofa, Golam, Quamruzzaman, Quazi, Rahman, Mahmuder, Tarantini, Letizia, Wright, Robert O.   +10 more
core   +2 more sources

Mixing state of oxalic acid containing particles in the rural area of Pearl River Delta, China: implications for the formation mechanism of oxalic acid [PDF]

Atmospheric Chemistry and Physics, 2017
The formation of oxalic acid and its mixing state in atmospheric particulate matter (PM) were studied using a single-particle aerosol mass spectrometer (SPAMS) in the summer and winter of 2014 in Heshan, a supersite in the rural area of the Pearl ...
C. Cheng, C. Cheng, M. Li, M. Li, C. K. Chan, H. Tong, C. Chen, D. Chen, D. Wu, D. Wu, L. Li, L. Li, C. Wu, C. Wu, P. Cheng, P. Cheng, W. Gao, W. Gao, Z. Huang, Z. Huang, X. Li, X. Li, Z. Zhang, Z. Zhang, Z. Fu, Y. Bi, Z. Zhou, Z. Zhou   +27 more
doaj   +1 more source