Results 51 to 60 of about 4,813,932 (329)

RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition [PDF]

, 2018
Long INterspersed Element class 1 (LINE-1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition-competent LINE-1s, whose activity is influenced by the combined action ...
Benitez-Guijarro, Maria, Cano, David, Fluteau, Adeline, Garcia-Cañadas, Marta, Garcia-Perez, Jose L., Heras, Sara R, Jackson, Andrew P., Kempen, Marie-Jeanne, Lopez-Ruiz, Cesar, Mohammad, Mahwish Mian, Murina, Olga, Reijns, Martin A. M., Sanchez, Laura, Sanchez-Pozo, Antonio, Tamauskaite, Zygimante, Vilar-Astasio, Raquel, Williams, Thomas C.   +16 more
core   +3 more sources

Alu and LINE-1 methylation and lung function in the normative ageing study [PDF]

, 2012
Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration facilities in greater Boston,
Baccarelli, Andrea, Bollati, Valentina, Demeo, Dawn Lisa, Lange, Nancy E, Litonjua, Augusto Ampil, Schwartz, Joel David, Sordillo, Joanne, Sparrow, David, Tarantini, Letizia, Vokonas, Pantel, Zanobetti, Antonella   +10 more
core   +2 more sources

Validation of corporate probability of default models considering alternative use cases and the quantification of model risk

Data Science in Finance and Economics, 2022
In this study we consider the construction of through-the-cycle ("TTC") probability-of-default ("PD") models designed for credit underwriting uses and point-in-time ("PIT") PD models suitable for early warning uses, considering which validation elements ...
Michael Jacobs Jr.
doaj   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

The Reverse Transcriptase Encoded by LINE-1 Retrotransposons in the Genesis, Progression, and Therapy of Cancer [PDF]

, 2016
In higher eukaryotic genomes, Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons represent a large family of repeated genomic elements. They transpose using a reverse transcriptase (RT), which they encode as part of the ORF2p product.
Chiara De Luca, Corrado Spadafora, Ilaria Sciamanna   +2 more
core   +2 more sources

Identifying the genetic basis for resistance to avian influenza in commercial egg layer chickens

Animal, 2018
Two highly pathogenic avian influenza (HPAI) outbreaks have affected commercial egg production flocks in the American continent in recent years; a H7N3 outbreak in Mexico in 2012 that caused 70% to 85% mortality and a H5N2 outbreak in the United States ...
W. Drobik-Czwarno, A. Wolc, J.E. Fulton, J. Arango, T. Jankowski, N.P. O’Sullivan, J.C.M. Dekkers   +6 more
doaj   +1 more source

Do Small RNAs Interfere With LINE‐1? [PDF]

BioMed Research International, 2006
Long interspersed elements (LINE‐1 or L1) are the most active transposable elements in the human genome. Due to their high copy number and ability to sponsor retrotransposition of nonautonomous RNA sequences, unchecked L1 activity can negatively impact the genome by a number of means.
openaire   +2 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Retrotransposon-Encoded Reverse Transcriptase in the Genesis, Progression and Cellular Plasticity of Human Cancer [PDF]

, 2011
LINE-1 (Long Interspersed Nuclear Elements) and HERVs (Human Endogenous Retroviruses) are two families of autonomously replicating retrotransposons that together account for about 28% of the human genome.
Matteucci, C, Sinibaldi Vallebona, P, Spadafora, C   +2 more
core   +2 more sources

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source