Results 241 to 250 of about 17,428,143 (356)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Commentary on "Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion". [PDF]

Neurospine
Kanda Y.
europepmc   +2 more sources

Novel psychophysical line bisection task using brief stimulus presentation reveals no horizontal bias in left-onset parkinson's disease. [PDF]

Sci Rep
Norton DJ, Munro CE, Williams A, Gallart-Palau X, Cronin-Golomb A.   +4 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Underwater internal traction-assisted reopenable clip-over-the-line method for full-thickness defect closure in a gastric collapse. [PDF]

Endoscopy
Nomura T, Ichikawa K, Hatanaka T, Setsuda M, Hamada T, Kaneko H, Mukai K.   +6 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Little red dots as young supermassive black holes in dense ionized cocoons. [PDF]

Nature
Rusakov V, Watson D, Nikopoulos GP, Brammer G, Gottumukkala R, Harvey T, Heintz KE, Damgaard R, Sim SA, Sneppen A, Vijayan AP, Adams N, Austin D, Conselice CJ, Goolsby CM, Toft S, Witstok J.   +16 more
europepmc   +1 more source

LINE-1 hypermethylation in peripheral blood of cutaneous melanoma patients is associated with metastasis

, 2015
Érica Sara Souza de Araújo, André Yoshiaki Kashiwabara, Maria Isabel Achatz, Luciana Facure Moredo, Bianca Costa Soares de Sá, João Pedreira Duprat Neto, Carla Rosenberg, Dirce Maria Carraro, Ana Cristina Victorino Krepischi   +8 more
openalex   +1 more source