Results 91 to 100 of about 13,917,092 (356)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Waterfall plot of treatment-free interval following first-line therapy.
, 2020 Waterfall plot of treatment-free interval following first-line therapy.
Toby A. Eyre (8479401) +7 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Score following: An artificially intelligent musical accompanist [PDF]
Score Following is the process by which a musician can be tracked through their performance of a piece, for the purpose of accompanying the musician with the appropriate notes.
Jordanous, Anna
core
Itacitinib in advanced hepatocellular cancer following first line therapy
npj Precision OncologyHepatocellular carcinoma (HCC) develops on background chronic liver disease where uncontrolled inflammation drives hepatocarcinogenesis. First-line therapies have limited response.
Alessandro Troiani +11 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Obstacle Avoidance and Line Following 2WD Robot
, 2020 We use autonomous line-following robots in various industrial environments, surveillance applications, and construction and mining industries for object transportation tasks where rail, conveyer, and gantry solutions are unavailable.
Sai Chaya Mounika, Mudragada +1 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Advanced Research in Science, Communication and TechnologyIn the realm of autonomous robotics, line following robots represent an essential stepping stone toward advanced automated systems. This paper introduces a smart line follower robot enhanced with adaptive path correction using ultrasonic sensors. Unlike traditional line followers that rely solely on infrared (IR) sensors for navigation, our approach ...
null Somesh D H, null Dr. R. Aruna
openaire +1 more source