Results 71 to 80 of about 12,819,566 (246)
Itacitinib in advanced hepatocellular cancer following first line therapy
npj Precision OncologyHepatocellular carcinoma (HCC) develops on background chronic liver disease where uncontrolled inflammation drives hepatocarcinogenesis. First-line therapies have limited response.
Alessandro Troiani +11 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Tasmanian main line railway [cartographic material].
, 1880 Map showing the main railway line from Hobart to Launceston in red, the Mersey, Deloraine, Launceston and Western Railway in black and the projected line from Bridgewater in a broken red line.; Australian Encyclopedia, 6th ed., v. 7, p.
core
PERFORMANCE FOLLOWING: TRACKING A PERFORMANCE WITHOUT A SCORE [PDF]
, 2010 EPSRC Doctoral Training Award; EPSRC Leadership ...
Plumbley, MD +3 more
core +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Score following: An artificially intelligent musical accompanist [PDF]
Score Following is the process by which a musician can be tracked through their performance of a piece, for the purpose of accompanying the musician with the appropriate notes.
Jordanous, Anna
core
IEEE Access, 2019 This paper investigates the path following problem for an underactuated unmanned surface vehicle (USV) in the presence of ocean currents, model uncertainties and input saturation.
Mingcong Li, Chen Guo, Haomiao Yu
doaj +1 more source