Results 111 to 120 of about 6,905,915 (330)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Jixie chuandong, 2022 The current theory considers that the shape of the deformed flexspline tooth ring neutral line is an isometric line of the cam, which ignores the effect of fit clearance and neutral line's elongation.
Xing Jingzhong +3 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
On Plastic Design of Rotating Complex Machine Elements
Engineering Transactions, 1992 The differential relations (analoguous to Henecky equations) along slip-lines in the presence of body forces are formulated. These relations may be used in constructing stress fields for plastic design of various machine elements undergoing large body ...
W. Zowczak
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Механика машин, механизмов и материалов, 2019 The method of determining the force factors from the dynamic aftereffect of the shock at capture of metal by rolls of blooming mill is introduced. The differential equations of motion for the main line of the blooming mill are composed taking into ...
Tamaz M. Natriashvili, Slava A. Mebonia
doaj
Scientia Militaria, 2012 The previous articles in this series dealt firstly with the background to and occupation by Allied forces of Diego Suarez in May 1942, and secondly with the early role of the South African Air Force in that operation.
J.E.D. Grobler
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The development of an innovative SME-focused toolset integrating carbon footprint calculation with lean manufacturing waste reduction techniques [PDF]
, 2008 This paper seeks to explore the role that SMEs can play in the drive to reduce UK greenhouse gas (GHG) emissions in line with the recent European Union (EU) targets; a 30% reduction by 2020 and a 60% reduction by 2050 (DEFRA, 2007).
Lambert, Christopher +2 more
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