Results 81 to 90 of about 6,905,915 (330)

Critical Casimir effects in 2D Ising model with curved defect lines

, 2017
This work is aimed at studying the influence of critical Casimir effects on energetic properties of curved defect lines in the frame of 2D Ising model. Two types of defect curves were investigated.
Mostovoy, Sergey D., Pavlovsky, Oleg V.
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells

Scientific Reports
During metastatic dissemination, circulating tumour cells (CTCs) enter capillary beds, where they experience mechanical constriction forces. The transient and persistent effects of these forces on CTCs behaviour remain poorly understood.
Julia Perea Paizal, Sam H. Au, Chris Bakal   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Vortex-Induced Vibration Tests of a Marine Growth Wrapped Cylinder at Subcritical Reynolds Number

MATEC Web of Conferences, 2017
Vortex Induced Vibrations (VIV) may cause great damage to deep water risers. Estimation of accurate hydrodynamic coefficients and response amplitudes for fouled tubular cylinders subjected to VIVs is a complex task.
Kurian V. J., Al-Yacouby A. M., Khir A. R. M.   +2 more
doaj   +1 more source

Melting of Flux Lines in an Alternating Parallel Current

, 1998
We use a Langevin equation to examine the dynamics and fluctuations of a flux line (FL) in the presence of an {\it alternating longitudinal current} $J_{\parallel}(\omega)$.
A. E. Koshelev, A. I. Larkin, B. Khaykovich, D. Ertas, D. Ertas, D. Ertas, D. Ertas, D. R. Nelson, D. R. Nelson, D. R. Nelson, D. S. Fisher, E. H. Brandt, E. H. Brandt, E. H. Brandt, E. H. Brandt, G. Blatter, G. D’Anna, G. D’Anna, I. S. Aranson, J. Bardeen, L. Radzihovsky, L. Tang, M. P. A. Fisher, M. P. A. Fisher, M. V. Feigel’man, M. Wallin, Mehran Kardar, Mohammad Kohandel, R. K. P. Zia, R. Kamien, T. Giamarchi, T. Giamarchi, T. Giamarchi, W. Krauth, W. S. Seow, Y. Y. Goldschmidt   +35 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Filtered lifting line theory and application to the actuator line model

Journal of Fluid Mechanics, 2018
Lifting line theory describes the cumulative effect of shed vorticity from finite span lifting surfaces. In this work, the theory is reformulated to improve the accuracy of the actuator line model (ALM).
L. Martínez‐Tossas, C. Meneveau
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Applications of On-Line Monitoring of Dynamic Forces Experienced by Needles during Formation of Needled Fabrics [PDF]

, 1999
Abdel‐Fattah M. Seyam
openalex   +3 more sources