Results 91 to 100 of about 5,298,176 (299)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

3D Organoid Formation from the Murine Salivary Gland Cell Line SIMS

open access: yesBio-Protocol, 2019
Salivary glands consist of multiple phenotypically and functionally unique cell populations, such as the acinar, ductal, and myoepithelial cells that help produce, modify, and secrete saliva (Lombaert et al., 2011).
Harleen Athwal, Isabelle Lombaert
doaj   +1 more source

Formation depths of Fraunhofer lines

open access: yes, 2015
We have summed up our investigations performed in 1970--1993. The main task of this paper is clearly to show processes of formation of spectral lines as well as their distinction by validity and by location. For 503 photospheric lines of various chemical elements in the wavelength range 300--1000 nm we list in Table the average formation depths of the ...
Gurtovenko, E. A., Sheminova, V. A.
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Influence of Chromospheric Activity on Line Formation

open access: yesThe Astrophysical Journal
One of the primary sources of stellar spectral variability is magnetic activity. While our current understanding of chromospheric activity is largely derived from specific lines sensitive to chromospheric heating, such as the Ca ii H and K doublet ...
Mariela C. Vieytes   +2 more
doaj   +1 more source

Quasar Black Hole Mass Estimates from High-Ionization Lines: Breaking a Taboo?

open access: yesAtoms, 2017
Can high ionization lines such as CIV λ 1549 provide useful virial broadening estimators for computing the mass of the supermassive black holes that power the quasar phenomenon?
Paola Marziani   +7 more
doaj   +1 more source

Molecular Emission Line Formation in Prestellar Cores

open access: yes, 2008
We investigate general aspects of molecular line formation under conditions which are typical of prestellar cores. Focusing on simple linear molecules, we study formation of their rotational lines by radiative transfer simulations.
B. Shustov   +13 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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