Results 91 to 100 of about 168,150,866 (290)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

On area comparison and rigidity involving the scalar curvature [PDF]

In this thesis we study the effects of lower bounds for the curvature of a Riemannian manifold M on the geometry and topology of closed, minimal hypersurfaces.
Moraru, Vlad
core  

Identification of Local Lubrication Regimes on Textured Surfaces by 3D Roughness Curvature Radius [PDF]

, 2014
This paper proposes a new method of 3D roughness peaks curvature radius calculation and its application to tribological contact analysis as a characteristic signature of tribological contact.
Bigerelle, M., Bigerelle, M, Dubar, L., L. Dubar, Kubiak, KJ, C. Hubert, Hubert, C., M. Bigerelle, K. J. Kubiak, Bigerelle, Maxence, Hubert, Cedric, Dubar, Laurent, Kubiak, Krzysztof, Dubar, L, Kubiak, K. J., Hubert, C   +15 more
core   +1 more source

Automatic Analysis of Trough Lines Based on Curvature Tracing

Atmosphere, 2018
To solve the problems that arise in traditional automatic methods for trough line analysis with regard to low processing efficiency and analytical accuracy, an automatic method for trough line analysis was proposed in this study, comprising the following
Qian Li, Yan Huang, Yin Fan, Shaoen Tang, Yuntao Hu   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

TEXAS FIELD CROPS: ESTIMATION WITH CURVATURE [PDF]

Some implications of theory are easily maintained in econometric estimation, but computational costs of maintaining curvature properties (sufficient for existence of an optimal solution) have often proved prohibitive.
Shumway, C. Richard, Talpaz, Hovav, Alexander, William P.   +2 more
core  

A Survey of Magnetic Field Line Curvature in Jovian Dawn Magnetodisc

Geophysical Research Letters
The Jovian magnetosphere is highly dynamic, influenced by both solar wind and internal processes associated with the rapid planetary rotation and Io's volcanic activities.
W. D. Gu, Z. H. Yao, Y. Wei, T. S. Qin, B. Z. Zhang, Y. Xu, W. R. Dunn, P. A. Delamere, Y. N. Chen   +8 more
doaj   +1 more source

Stretching and curvature of material lines in chaotic flows [PDF]

Physica D: Nonlinear Phenomena, 2004
14 pages, 9 figures.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source