Results 81 to 90 of about 168,150,866 (290)
工程科学与技术, 2017 :The curvature relationship of the conjugate tooth surface of gear pair is the important parameter which is the characterization of gear transmission quality,and has a direct effect on the induced normal curvature,contact zone shape,contact property ...
Wei Yongqiao +5 more
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Modeling and computation of two phase geometric biomembranes using surface finite elements [PDF]
, 2010 Biomembranes consisting of multiple lipids may involve phase separation phenomena leading to coexisting domains of different lipid compositions.
Stinner, Björn, Elliott, Charles M.
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Novel geometric features for off-line writer identification [PDF]
, 2016 Writer identification is an important field in forensic document examination. Typically, a writer identification system consists of two main steps: feature extraction and matching and the performance depends significantly on the feature extraction step ...
Al-Maadeed, Somaya +3 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Orientation tuning of curvature adaptation reveals both curvature-polarity-selective and non-selective mechanisms [PDF]
, 2009 We have used a curvature after-effect, or CAE, to explore whether curvature detectors are tuned for the overall orientation of a curve. CAEs were measured for half-cycle cosine-shaped contours as a function of adaptor contour orientation for a fixed test
Jason Bell +5 more
core +1 more source
Curvature-Driven Migration of Colloids on Tense Lipid Bilayers
, 2016 Inspired by proteins that generate membrane curvature, sense the underlying membrane geometry, and migrate driven by curvature gradients, we explore the question: Can colloids, adhered to lipid bilayers, also sense and respond to membrane geometry?
Ningwei Li (3609548) +6 more
core +2 more sources
BMC OphthalmologyPurpose To investigate a novel marker to diagnose posterior staphylomas by measuring the radius of the steepest curvature on the retinal pigment epithelium (RPE) segmentation line using optical coherence tomography (OCT). Study Design Retrospective Cross-
Sunho Park +5 more
doaj +1 more source