Results 61 to 70 of about 118,308 (264)

Multi-point forming springback compensation control oftwo-dimensional hull plate

Advances in Mechanical Engineering, 2020
Springback is always a technical problem in sheet metal forming. In this article, the rapid springback compensation control of two-dimensional hull plate is realized by theoretical calculation and numerical simulation.
Shaojuan Su, Yuchao Jiang, Yeping Xiong
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Characterization of fusion boundary between low alloy steel and stainless steel cladding

Journal of Materials Research and Technology
The microstructure and hardness of fusion boundary (FB) and near FB of a low alloy steel (LAS) 16MND5 welding cladded with stainless steel 308L for nuclear reactor pressure vessel were investigated by using modern electron microscopes and nano-indenter ...
Tingguang Liu, Qingfeng Wu, Yonggang Fang, Yimei Wang, Qibao Chu, Yinqiang Chen, Donghua Tian, Yonghao Lu, Tetsuo Shoji   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Computing method for induced curvature parameters based on normal vector of instantaneous contact line and its application to Hindley worm pair

Advances in Mechanical Engineering, 2017
The main objective of this article is to propose a practical methodology to compute the induced curvature parameters for a line-conjugated tooth surface couple based on the normal vector of its instantaneous contact line.
Yaping Zhao, Yimin Zhang
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Study on the Tooth Surface and Curvature Characteristics of Cylindrical Gear with Variable Hyperbolic Arc-tooth-trace

工程科学与技术, 2017
:The curvature relationship of the conjugate tooth surface of gear pair is the important parameter which is the characterization of gear transmission quality,and has a direct effect on the induced normal curvature,contact zone shape,contact property ...
Wei Yongqiao, Ma Dengqiu, Wu Yang, Luo Lan, Bai Qingsong, Hou Li   +5 more
doaj  

Surfaces with Isothermal Representation of Their Lines of Curvature and Their Transformations [PDF]

Transactions of the American Mathematical Society, 1908
IN a former lnemoir with the same title t we established a transformation of surfaces with isothermal spherical representation of their lines of curvature into surfaces of the same kind, the transformation being such that lines of curvature on a surface and on a transform correspond, and the two surfaces constitute the envelope of a two-parameter ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source