Results 131 to 140 of about 6,236,563 (298)
Profiles (Spring/Summer 2015) V. 14 (1)
, 2015 . (2015). Profiles (Spring/Summer 2015) V. 14 (1).
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Inference of the physical parameters of Hα-absorbing plasma structures in the quiet Sun
Astronomy & AstrophysicsOn-disk Hα light-absorbing plasma structures such as mottles, fibrils, filaments, and Hα jets are observable magnetohydrodynamic features in the upper solar chromosphere.
Chae Jongchul +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Phase- and Inclination-Dependent Line Profiles of 32 Cygni [PDF]
, 1992 The line profiles of 32 Cyg have been calculated by integrating the equation of transfer numerically. In order to determine the source function the two level atom and complete redistribution were assumed and Sobolev approximation was used.
Kyu-Hong Choi, Kyung-Mee Kim
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An Implementation of the Fundamental Parameters Approach for Analysis of X-ray Powder Diffraction Line Profiles. [PDF]
J Res Natl Inst Stand Technol, 2015 Mendenhall MH, Mullen K, Cline JP.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source