Results 161 to 170 of about 7,732,330 (302)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Immune regulation includes an effector arm: therapeutic implications of phase III IDO/PD-L1 vaccination in melanoma. [PDF]

Signal Transduct Target Ther
Andersen MH.
europepmc   +1 more source

Voltage regulation of transmission lines

Voltage regulation of transmission lines
種別 ...
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Impact of a physical-cognitive intervention on emotional regulation and school adjustment in primary school children. [PDF]

Front Psychol
Carcelén-Fraile MDC, Montánchez-Torres ML.   +1 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A comprehensive map of the bovine mobilome and their epigenetic regulation of mastitis. [PDF]

Funct Integr Genomics
Yang N, Wang M, Abanda Mbili SE, Vincent AT, Song C, Ibeagha-Awemu EM.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Designing Low Dropout Regulator with Low Settling Time, High Power Supply Rejection and Low Line and Load Regulation

Majlesi Journal of Electrical Engineering
Low dropout regulators are one of the most important factures of many portable devices. Thus, consider to the complexity of the circuits and increasing request for portable devices, for increasing battery life and minimizing supply noise, regulators with
Najmeh Khanian, Abbas Golmakani
doaj  

Global trade responses to shark finning regulations. [PDF]

Nat Commun
Burns ES, Orofino S, Wang K, Bradley D, D'Costa NG, Feitosa LM, Schiller L, Worm B, Gephart JA, McDonald GG.   +9 more
europepmc   +1 more source