Results 71 to 80 of about 19,173 (257)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Combining ability and gene action analysis in sunflower(Helianthus annuus L.)

Electronic Journal of Plant Breeding, 2020
The present investigation was made to study the combining ability and gene action in sunflower. Five standard CMS lines and nine restorers were included as parental material.
P. H. Karande, M. K. Ghodake, A. M. Misal and P. L. Tavadare
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Combining ability analysis for grain yield and its contributing traits in maize (Zea mays L.) over environments

Electronic Journal of Plant Breeding, 2017
Combining ability analysis for grain yield and its contributing traits in maize was performed with 15 inbred line and 3 tester parents and the resulting 45 hybrids using line x tester cross analysis in three environments during kharif and rabi 2014. The
Baudh Bharti, R.B. Dubey, Arun Kumar, H.N. Bind and, B.S. Jat   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

AVALIAÇÃO DE LINHAGENS S3 DE MILHO POR MEIO DE TESTADORES ADAPTADOS À SAFRINHA

Revista Caatinga, 2015
Several breeding programs aim to develop superior maize genotypes able to be explored in off-season cropping, mainly due to the increased area under maize produced in alternative season.
LUIZ RAFAEL CLOVIS, CARLOS ALBERTO SCAPIM, RONALD JOSÉ BARTH PINTO, EDSON BOLSON, HENRIQUE JOSÉ CAMARGO SENHORINHO   +4 more
doaj  

Combining ability and gene action analysis for yield and yield attributing traits in rice (Oryza sativa.L)

Electronic Journal of Plant Breeding, 2020
Six lines and four testers were involved in the combining ability and gene action study in line x tester mating design to discern desirable general and specific combiner for breeding programme.
L. AnandaLekshmi, S. Geetha, K.Amudha, R. Muthuvijayaragavan and D. Uma
doaj   +1 more source

Heterosis studies in sesame (Sesamum indicum L.)

Electronic Journal of Plant Breeding, 2017
Heterosis for seed yield and its components was studied in a set of line x tester crosses of 10 lines and 5 testers. The analysis of variance revealed highly significant differences among the genotypes for all the characters indicating that the ...
M.B. Virani, J.H. Vachhani, V.H. Kachhadia, R.M. Chavadhari and, R.A. Mungala   +4 more
doaj   +1 more source