Results 81 to 90 of about 19,173 (257)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Genetic studies of quantitative traits in interspecific hybrids of tetraploid cotton (Gossypium hirsutum L. X Gossypium barbadense L.) [PDF]
Electronic Journal of Plant Breeding, 2014 Forty five inter specific hybrids between tetraploid species, G. hirsutum x G. barbadense derived involving nine diverse female parents of G.hirsutum and five pollen parents of G.barbadense were evaluated to study heterosis and combining ability for seed
B. N. Patel, N. A. Patel, N. V. Soni and V. D. Dave
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Assessment of combining ability for yield and yield contributing traits in sweet corn
Electronic Journal of Plant Breeding, 2020 An investigation was carried out to assess the combining ability and nature of gene action in sweet corn genotypes using Line x Tester mating design using ten lines and five testers.
R. Ravikesavan, B. Suhasini, A. Yuvaraja and N. KumariVinodhana
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Heterosis in relation to combining ability for yield and quality attributes in Brinjal (Solanum melongena L.) [PDF]
Electronic Journal of Plant Breeding, 2010 Genetical studies on fruit yield per plant and its attributing traits alongwith quality traits like total soluble solids (TSS) andrind thickness were conducted following line x tester mating design comprising of 8 lines and 6 testers at ...
Abhinav Sao and Nandan Mehta
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source